Manganese(III) acetate mediated oxidative radical cyclizations of α-substituted N-[2-(phenylethynyl)phenyl]acetamides

Che Ping Chuang, Yan Jhu Chen

研究成果: Article同行評審

17 引文 斯高帕斯(Scopus)

摘要

An effective method for the synthesis of 3,4-disubstituted quinolin-2(1H)-ones was reported. α-Carbonylalkyl radical, produced by the manganese(III) acetate oxidation of α-substituted N-[2-(phenylethynyl)phenyl]acetamides, undergoes a 6-exo-dig cyclization onto the C-C triple bond efficiently and 3,4-disubstituted quinolin-2(1H)-ones were produced. Heterocyclic substrates could also be used to generate the corresponding quinolin-2(1H)-ones smoothly. A variety of functional groups, including methoxycarbonyl, cyano, diethoxyphosphoryl and benzoyl groups, are compatible with the reaction conditions. Under Mn(II)/Co(II)/O2 conditions, the formation of these quinolin-2(1H)-ones could also be achieved from the corresponding N-[2-(phenylethynyl)phenyl]acetamides and a catalytic amount of manganese(II) acetate was used.

原文English
頁(從 - 到)1911-1918
頁數8
期刊Tetrahedron
72
發行號16
DOIs
出版狀態Published - 2016 四月 21

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 藥物發現
  • 有機化學

指紋

深入研究「Manganese(III) acetate mediated oxidative radical cyclizations of α-substituted N-[2-(phenylethynyl)phenyl]acetamides」主題。共同形成了獨特的指紋。

引用此