@article{c3a7f33724ad4c7a8a75bc2204156116,
title = "Manipulating Cellular Activities Using an Ultrasound-Chemical Hybrid Tool",
abstract = "We developed an ultrasound-chemical hybrid tool to precisely manipulate cellular activities. A focused ultrasound coupled with gas-filled microbubbles was used to rapidly trigger the influx of membrane-impermeable chemical dimerizers into living cells to regulate protein dimerization and location without inducing noticeable toxicity. With this system, we demonstrated the successful modulation of phospholipid metabolism triggered by a short pulse of ultrasound exposure. Our technique offers a powerful and versatile tool for using ultrasound to spatiotemporally manipulate the cellular physiology in living cells.",
author = "Fan, {Ching Hsiang} and Huang, {Yao Shen} and Huang, {Wei En} and Lee, {Albert Alexander} and Ho, {Sheng Yang} and Kao, {Yu Lin} and Wang, {Cuei Ling} and Lian, {Yen Ling} and Tasuku Ueno and {Andrew Wang}, {Tsung Shing} and Yeh, {Chih Kuang} and Lin, {Yu Chun}",
note = "Funding Information: We thank Dr. Takanari Inoue at Johns Hopkins University School of Medicine for sharing the DNA constructs. We are grateful to Dr. Hwan-You Chang at National Tsing Hua University for sharing the C2BBe1 cell lines. This work was partially supported by the Ministry of Science and Technology (MOST), Taiwan (MOST 105-2113-M-002-003 to T.S.A.W., MOST 105-2221-E-007-055 and MOST 105-2119-M-182-001 to C.K.Y., MOST 104-2311-B-007-001, MOST 105-2628-B-007-001-MY3, and Program for Translational Innovation of Biopharmaceutical Development-Technology Supporting Platform Axis-nMACS imaging to Y.C.L., and start-up funds from the National Tsing Hua University to Y.C.L. Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",
year = "2017",
month = nov,
day = "17",
doi = "10.1021/acssynbio.7b00162",
language = "English",
volume = "6",
pages = "2021--2027",
journal = "ACS Synthetic Biology",
issn = "2161-5063",
publisher = "American Chemical Society",
number = "11",
}