TY - JOUR
T1 - Maternal anemia and the risk of childhood cancer
T2 - A population-based cohort study in Taiwan
AU - Orimoloye, Helen T.
AU - Qureshi, Naveen
AU - Lee, Pei Chen
AU - Wu, Chia Kai
AU - Saechao, Chai
AU - Federman, Noah
AU - Li, Chung Yi
AU - Ritz, Beate
AU - Arah, Onyebuchi A.
AU - Heck, Julia E.
N1 - Funding Information:
This work was supported by a grant from Alex's Lemonade Stand Foundation (grant number 17‐01882). Ms. Qureshi was supported by a stipend from Columbia University Mailman School of Public Health. Dr. Federman was supported by NIH/NCATS Grant #UL1TR001881.
Publisher Copyright:
© 2023 Wiley Periodicals LLC.
PY - 2023/3
Y1 - 2023/3
N2 - Background: Childhood cancer may be related to maternal health in pregnancy. Maternal anemia is a common condition in pregnancy, especially in low-income countries, but the association between maternal anemia and childhood cancer has not been widely studied. Objective: To examine the potential relation between maternal anemia during pregnancy and childhood cancers in a population-based cohort study in Taiwan. Methods: We examined the relationship between maternal anemia and childhood cancer in Taiwan (N = 2160 cancer cases, 2,076,877 noncases). Cases were taken from the National Cancer Registry, and noncases were selected from birth records. Using national health registries, we obtained maternal anemia diagnoses. We estimated the risks for childhood cancers using Cox proportional hazard analysis. Results: There was an increased risk of cancers in children born to mothers with nutritional anemia (hazard ratio (HR): 1.32, 95% CI 0.99, 1.76). Iron deficiency anemia (HR: 1.30, 95% CI 0.97–1.75) carried an increased risk, while non-nutritional anemias were not associated with childhood cancer risk. Conclusion: Our results provide additional support for screening for anemia during pregnancy. Adequate nutrition and vitamin supplementation may help to prevent some childhood cancer.
AB - Background: Childhood cancer may be related to maternal health in pregnancy. Maternal anemia is a common condition in pregnancy, especially in low-income countries, but the association between maternal anemia and childhood cancer has not been widely studied. Objective: To examine the potential relation between maternal anemia during pregnancy and childhood cancers in a population-based cohort study in Taiwan. Methods: We examined the relationship between maternal anemia and childhood cancer in Taiwan (N = 2160 cancer cases, 2,076,877 noncases). Cases were taken from the National Cancer Registry, and noncases were selected from birth records. Using national health registries, we obtained maternal anemia diagnoses. We estimated the risks for childhood cancers using Cox proportional hazard analysis. Results: There was an increased risk of cancers in children born to mothers with nutritional anemia (hazard ratio (HR): 1.32, 95% CI 0.99, 1.76). Iron deficiency anemia (HR: 1.30, 95% CI 0.97–1.75) carried an increased risk, while non-nutritional anemias were not associated with childhood cancer risk. Conclusion: Our results provide additional support for screening for anemia during pregnancy. Adequate nutrition and vitamin supplementation may help to prevent some childhood cancer.
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U2 - 10.1002/pbc.30188
DO - 10.1002/pbc.30188
M3 - Article
C2 - 36600459
AN - SCOPUS:85145701919
SN - 1545-5009
VL - 70
JO - Medical and Pediatric Oncology
JF - Medical and Pediatric Oncology
IS - 3
M1 - e30188
ER -