Matrix metalloproteinases in stem cell regulation and cancer

Kai Kessenbrock, Chih Yang Wang, Zena Werb

研究成果: Review article

103 引文 (Scopus)

摘要

Since Gross and Lapiere firstly discovered matrix metalloproteinases (MMPs) as important collagenolytic enzymes during amphibian tadpole morphogenesis in 1962, this intriguing family of extracellular proteinases has been implicated in various processes of developmental biology. However, the pathogenic roles of MMPs in human diseases such as cancer have also garnered widespread attention. The most straightforward explanation for their role in cancer is that MMPs, through extracellular matrix degradation, pave the way for tumor cell invasion and metastasis. While this notion may be true for many circumstances, we now know that, depending on the context, MMPs may employ additional modes of functionality. Here, we will give an update on the function of MMPs in development and cancer, which may directly regulate signaling pathways that control tissue homeostasis and may even work in a non-proteolytic manner. These novel findings about the functionality of MMPs have important implications for MMP inhibitor design and may allow us to revisit MMPs as drug targets in the context of cancer and other diseases.

原文English
頁(從 - 到)184-190
頁數7
期刊Matrix Biology
44-46
DOIs
出版狀態Published - 2015 五月 1

指紋

Neoplastic Stem Cells
Matrix Metalloproteinases
Neoplasms
Developmental Biology
Matrix Metalloproteinase Inhibitors
Amphibians
Morphogenesis
Extracellular Matrix
Larva
Homeostasis
Peptide Hydrolases
Neoplasm Metastasis
Enzymes
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Molecular Biology

引用此文

Kessenbrock, Kai ; Wang, Chih Yang ; Werb, Zena. / Matrix metalloproteinases in stem cell regulation and cancer. 於: Matrix Biology. 2015 ; 卷 44-46. 頁 184-190.
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Matrix metalloproteinases in stem cell regulation and cancer. / Kessenbrock, Kai; Wang, Chih Yang; Werb, Zena.

於: Matrix Biology, 卷 44-46, 01.05.2015, p. 184-190.

研究成果: Review article

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