This paper presents results of a series of uniaxial and triaxial tests on specimens prepared from artificial anisotropic rock blocks created by high-pressure compaction of layers of different mixtures of cement, sand, microsilica and kaolinite. Artificial anisotropic rock specimens were cored with different dip angles from interlayered and stratified blocks. The Young's moduli of rock masses with different dip angle were simulated using the imperfectly bonded interface constitutive law developed by Tien et al. (1995). The simulation results based on the imperfect bonded models agreed well with the experimental results.