Mechanical control of stem cell differentiation using microengineered matrix

Jianping Fu, Yang-Gao Wang, Michael T. Yang, Ted T. Lee, Christopher S. Chen

研究成果: Paper同行評審

摘要

In this work, we explore the molecular mechanisms by which local mechanical properties (e.g., rigidity) of the extracellular matrix (ECM) cooperates with soluble cues to regulate lineage commitment of human mesenchymal stem cells (hMSCs). We have established different micropost array substrates that can definitively decouple matrix rigidity from other properties including adhesiveness. We applied these substrates to investigate the influences of matrix rigidity on cell adhesion, cytoskeleton assembly/contractility, cell spreading, and proliferation. We further show that matrix rigidity regulates commitment of hMSCs to either adipogenic or osteogenic fate: soft matrix facilitates adipogenic differentiation while stiff matrix proves osteogenic.

原文English
頁面1229-1231
頁數3
出版狀態Published - 2008 一月 1
事件12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States
持續時間: 2008 十月 122008 十月 16

Other

Other12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
國家United States
城市San Diego, CA
期間08-10-1208-10-16

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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