Mechanical evaluation of topical silicone gel on skin wound healing

C. H. Chiang, C. S. Yang, C. H. Yeh, M. Y. Chen, Fong-chin Su, C. Y. Liu, C. Y. Chen, Ming-Long Yeh

研究成果: Conference contribution

摘要

Dermatix is a Food and Drug Administration (FDA) registered treatment for hypertrophic scars and keloids. Some studies have evaluated its effects on scars and tried to find out its mechanism of effectiveness. However, there were few papers discussing about the mechanical properties of wounds after treated with Dermatix. Thus, our study aims to conduct tensile test to analyze the condition of skin wound treated with Dermatix and compare the results to the non-treated wounds. We evaluated the wound healing condition at 1, 2, 4 and 6 weeks healing time and introduced recovery index to normalize the different growing condition of each rats. The results showed that during healing time 4-6 weeks, both wounds recovered rapidly. And in all the healing time, Dermatix treated group showed better tensile strength and better recovery index. However, no significant difference was found at all healing time. We guess it is occlusion, hydration and normalization of TEWL effects of Dermatix that help collagen synthesize.

原文English
主出版物標題NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference
DOIs
出版狀態Published - 2009 九月 21
事件IEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009 - Boston, MA, United States
持續時間: 2009 四月 32009 四月 5

出版系列

名字Bioengineering, Proceedings of the Northeast Conference
ISSN(列印)1071-121X

Other

OtherIEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009
國家United States
城市Boston, MA
期間09-04-0309-04-05

指紋

Silicone Gels
Silicones
Skin
Gels
Recovery
Collagen
Hydration
Rats
Tensile strength
Mechanical properties

All Science Journal Classification (ASJC) codes

  • Bioengineering

引用此文

Chiang, C. H., Yang, C. S., Yeh, C. H., Chen, M. Y., Su, F., Liu, C. Y., ... Yeh, M-L. (2009). Mechanical evaluation of topical silicone gel on skin wound healing. 於 NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference [4967834] (Bioengineering, Proceedings of the Northeast Conference). https://doi.org/10.1109/NEBC.2009.4967834
Chiang, C. H. ; Yang, C. S. ; Yeh, C. H. ; Chen, M. Y. ; Su, Fong-chin ; Liu, C. Y. ; Chen, C. Y. ; Yeh, Ming-Long. / Mechanical evaluation of topical silicone gel on skin wound healing. NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference. 2009. (Bioengineering, Proceedings of the Northeast Conference).
@inproceedings{c270c11aaa4644e794da9c28cd835a0c,
title = "Mechanical evaluation of topical silicone gel on skin wound healing",
abstract = "Dermatix is a Food and Drug Administration (FDA) registered treatment for hypertrophic scars and keloids. Some studies have evaluated its effects on scars and tried to find out its mechanism of effectiveness. However, there were few papers discussing about the mechanical properties of wounds after treated with Dermatix. Thus, our study aims to conduct tensile test to analyze the condition of skin wound treated with Dermatix and compare the results to the non-treated wounds. We evaluated the wound healing condition at 1, 2, 4 and 6 weeks healing time and introduced recovery index to normalize the different growing condition of each rats. The results showed that during healing time 4-6 weeks, both wounds recovered rapidly. And in all the healing time, Dermatix treated group showed better tensile strength and better recovery index. However, no significant difference was found at all healing time. We guess it is occlusion, hydration and normalization of TEWL effects of Dermatix that help collagen synthesize.",
author = "Chiang, {C. H.} and Yang, {C. S.} and Yeh, {C. H.} and Chen, {M. Y.} and Fong-chin Su and Liu, {C. Y.} and Chen, {C. Y.} and Ming-Long Yeh",
year = "2009",
month = "9",
day = "21",
doi = "10.1109/NEBC.2009.4967834",
language = "English",
isbn = "9781424443628",
series = "Bioengineering, Proceedings of the Northeast Conference",
booktitle = "NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference",

}

Chiang, CH, Yang, CS, Yeh, CH, Chen, MY, Su, F, Liu, CY, Chen, CY & Yeh, M-L 2009, Mechanical evaluation of topical silicone gel on skin wound healing. 於 NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference., 4967834, Bioengineering, Proceedings of the Northeast Conference, IEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009, Boston, MA, United States, 09-04-03. https://doi.org/10.1109/NEBC.2009.4967834

Mechanical evaluation of topical silicone gel on skin wound healing. / Chiang, C. H.; Yang, C. S.; Yeh, C. H.; Chen, M. Y.; Su, Fong-chin; Liu, C. Y.; Chen, C. Y.; Yeh, Ming-Long.

NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference. 2009. 4967834 (Bioengineering, Proceedings of the Northeast Conference).

研究成果: Conference contribution

TY - GEN

T1 - Mechanical evaluation of topical silicone gel on skin wound healing

AU - Chiang, C. H.

AU - Yang, C. S.

AU - Yeh, C. H.

AU - Chen, M. Y.

AU - Su, Fong-chin

AU - Liu, C. Y.

AU - Chen, C. Y.

AU - Yeh, Ming-Long

PY - 2009/9/21

Y1 - 2009/9/21

N2 - Dermatix is a Food and Drug Administration (FDA) registered treatment for hypertrophic scars and keloids. Some studies have evaluated its effects on scars and tried to find out its mechanism of effectiveness. However, there were few papers discussing about the mechanical properties of wounds after treated with Dermatix. Thus, our study aims to conduct tensile test to analyze the condition of skin wound treated with Dermatix and compare the results to the non-treated wounds. We evaluated the wound healing condition at 1, 2, 4 and 6 weeks healing time and introduced recovery index to normalize the different growing condition of each rats. The results showed that during healing time 4-6 weeks, both wounds recovered rapidly. And in all the healing time, Dermatix treated group showed better tensile strength and better recovery index. However, no significant difference was found at all healing time. We guess it is occlusion, hydration and normalization of TEWL effects of Dermatix that help collagen synthesize.

AB - Dermatix is a Food and Drug Administration (FDA) registered treatment for hypertrophic scars and keloids. Some studies have evaluated its effects on scars and tried to find out its mechanism of effectiveness. However, there were few papers discussing about the mechanical properties of wounds after treated with Dermatix. Thus, our study aims to conduct tensile test to analyze the condition of skin wound treated with Dermatix and compare the results to the non-treated wounds. We evaluated the wound healing condition at 1, 2, 4 and 6 weeks healing time and introduced recovery index to normalize the different growing condition of each rats. The results showed that during healing time 4-6 weeks, both wounds recovered rapidly. And in all the healing time, Dermatix treated group showed better tensile strength and better recovery index. However, no significant difference was found at all healing time. We guess it is occlusion, hydration and normalization of TEWL effects of Dermatix that help collagen synthesize.

UR - http://www.scopus.com/inward/record.url?scp=70349123107&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349123107&partnerID=8YFLogxK

U2 - 10.1109/NEBC.2009.4967834

DO - 10.1109/NEBC.2009.4967834

M3 - Conference contribution

SN - 9781424443628

T3 - Bioengineering, Proceedings of the Northeast Conference

BT - NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference

ER -

Chiang CH, Yang CS, Yeh CH, Chen MY, Su F, Liu CY 等. Mechanical evaluation of topical silicone gel on skin wound healing. 於 NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference. 2009. 4967834. (Bioengineering, Proceedings of the Northeast Conference). https://doi.org/10.1109/NEBC.2009.4967834