Mechanical evaluation of topical silicone gel on skin wound healing

C. H. Chiang, C. S. Yang, C. H. Yeh, M. Y. Chen, F. C. Su, C. Y. Liu, C. Y. Chen, M. L. Yeh

研究成果: Conference contribution

摘要

Dermatix is a Food and Drug Administration (FDA) registered treatment for hypertrophic scars and keloids. Some studies have evaluated its effects on scars and tried to find out its mechanism of effectiveness. However, there were few papers discussing about the mechanical properties of wounds after treated with Dermatix. Thus, our study aims to conduct tensile test to analyze the condition of skin wound treated with Dermatix and compare the results to the non-treated wounds. We evaluated the wound healing condition at 1, 2, 4 and 6 weeks healing time and introduced recovery index to normalize the different growing condition of each rats. The results showed that during healing time 4-6 weeks, both wounds recovered rapidly. And in all the healing time, Dermatix treated group showed better tensile strength and better recovery index. However, no significant difference was found at all healing time. We guess it is occlusion, hydration and normalization of TEWL effects of Dermatix that help collagen synthesize.

原文English
主出版物標題NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference
發行者Institute of Electrical and Electronics Engineers Inc.
ISBN(列印)9781424443628
DOIs
出版狀態Published - 2009
事件IEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009 - Boston, MA, United States
持續時間: 2009 4月 32009 4月 5

出版系列

名字Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
ISSN(列印)1071-121X

Other

OtherIEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009
國家/地區United States
城市Boston, MA
期間09-04-0309-04-05

All Science Journal Classification (ASJC) codes

  • 生物工程

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