Mechanical properties and biomedical application characteristics of degradable polylactic acid–Mg–Ca3(PO4)2 three-phase composite

Kuan Jen Chen, Fei Yi Hung, Yun Ting Wang, Chen Wei Yen

研究成果: Article同行評審

摘要

Polylactic acid (PLA), pure magnesium powder, and calcium phosphate powder were used to form a three-phase degradable biomedical composite. The effects of various powder proportions in polylactic acid–Mg–Ca3(PO4)2 composites were analyzed through mechanical and biological tests, which revealed that both the tensile and impact strength of the composite increased. Additionally, ductility presented only after a small proportion of powder was added. Hardness slightly increased because of dispersion strengthening. Furthermore, the addition of pure magnesium and calcium phosphate accelerated the degradation rate, and biocompatible salts were generated after degradation, which can improve healing and renewal in bone tissue. None of the composites exhibited cytotoxicity, meeting biological safety requirements. Overall, PLA10M10C (10 wt.% Mg, 10 wt.% Ca3(PO4)2) exhibited superior performance. Accordingly, PLA10M10C can serve as a reference for degradable biomedical material applications in orthopedic implants.

原文English
文章編號104949
期刊Journal of the Mechanical Behavior of Biomedical Materials
125
DOIs
出版狀態Published - 2022 1月

All Science Journal Classification (ASJC) codes

  • 生物材料
  • 生物醫學工程
  • 材料力學

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