Mechanical properties of collagen gels derived from rats of different ages

Ching Chou Wu, Shinn Jyh Ding, Yao Hsien Wang, Ming Jer Tang, Hsien Chang Chang

研究成果: Article

46 引文 斯高帕斯(Scopus)


In a previous study, we found that different collagen gels produced using collagen fibrils extracted from 1-, 4- and 8-month-old rat tails essentially influenced the morphogenesis of epithelial cells. More importantly, the youngest collagen gel induces the highest level of cell apoptosis. The objective of this study was to investigate mechanical properties of various collagen gels correlated to the rat ages. A rheometer and dynamic mechanical analyzer were used to measure shear and compressive properties of hydrated collagen gels. Experimental results obtained from both testing modes showed that older age-related collagen gels possessed a larger elastic modulus, possibly due to the enhanced cross-linking degree. The moduli obtained in shear mode were 1.4-2.7-times greater than those in compression. The results of shear test and compressive test consistently indicated the age of rats did have a statistically significant effect on mechanical properties of hydrated collagen gels.

頁(從 - 到)1261-1275
期刊Journal of Biomaterials Science, Polymer Edition
出版狀態Published - 2005 十月 1

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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