Mechanical regulation of cell function with geometrically modulated elastomeric substrates

Jianping Fu, Yang Kao Wang, Michael T. Yang, Ravi A. Desai, Xiang Yu, Zhijun Liu, Christopher S. Chen

研究成果: Article

653 引文 (Scopus)

摘要

We report the establishment of a library of micromolded elastomeric micropost arrays to modulate substrate rigidity independently of effects on adhesive and other material surface properties. We demonstrated that micropost rigidity impacts cell morphology, focal adhesions, cytoskeletal contractility and stem cell differentiation. Furthermore, early changes in cytoskeletal contractility predicted later stem cell fate decisions in single cells.

原文English
頁(從 - 到)733-736
頁數4
期刊Nature Methods
7
發行號9
DOIs
出版狀態Published - 2010 九月 1

指紋

Stem cells
Rigidity
Stem Cells
Cells
Focal Adhesions
Surface Properties
Substrates
Adhesives
Libraries
Surface properties
Cell Differentiation
Adhesion
elastomeric

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology

引用此文

Fu, Jianping ; Wang, Yang Kao ; Yang, Michael T. ; Desai, Ravi A. ; Yu, Xiang ; Liu, Zhijun ; Chen, Christopher S. / Mechanical regulation of cell function with geometrically modulated elastomeric substrates. 於: Nature Methods. 2010 ; 卷 7, 編號 9. 頁 733-736.
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Mechanical regulation of cell function with geometrically modulated elastomeric substrates. / Fu, Jianping; Wang, Yang Kao; Yang, Michael T.; Desai, Ravi A.; Yu, Xiang; Liu, Zhijun; Chen, Christopher S.

於: Nature Methods, 卷 7, 編號 9, 01.09.2010, p. 733-736.

研究成果: Article

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