Mechanical strength of bone allografts subjected to chemical sterilization and other terminal processing methods

Mark M. Mikhael, Paul M. Huddleston, Mark E. Zobitz, Quingshan Chen, Kristin D. Zhao, Kai Nan An

研究成果: Article同行評審

30 引文 斯高帕斯(Scopus)

摘要

Infectious disease transmission through the use of human donor allografts can be a catastrophic complication in an otherwise straightforward surgical procedure. The use of bone allograft in reconstructive orthopedic surgeries is increasing, yet severe complications, including death, can result if the transplanted tissues transmit a communicable disease to the tissue recipient. The BioCleanse® tissue sterilization process is a fully automated, low-temperature chemical sterilization process that renders allograft tissue sterile. The purpose of this study was to evaluate the effect of a chemical tissue sterilization process on the mechanical strength of cortical bone allografts prior to implantation. Cylindrical cortical bone specimens were harvested from seven human cadaver donors and treated either by: chemical sterilization alone; chemical sterilization and terminal sterilization by gamma irradiation; chemical sterilization, lyophilization, terminal sterilization by STERRAD and rehydration; or untreated. The specimens were tested to failure in axial compression, diametral compression, shear, or bending. There were no significant differences in ultimate stress, strain, or fracture energy between the chemically sterilized and control groups in any of the testing modes.

原文English
頁(從 - 到)2816-2820
頁數5
期刊Journal of Biomechanics
41
發行號13
DOIs
出版狀態Published - 2008 9月 18

All Science Journal Classification (ASJC) codes

  • 生物物理學
  • 生物醫學工程
  • 骨科和運動醫學
  • 復健

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