Mechanical testing and osteointegration of titanium implant with calcium phosphate bone cement and autograft alternatives

Dan Jae Lin, Chien Ping Ju, Shu Huei Huang, Yin Chun Tien, Hsiang Shu Yin, Wen Cheng Chen, Jiin Huey Chern Lin

研究成果: Article同行評審

10 引文 斯高帕斯(Scopus)

摘要

The purpose of this study was to evaluate the osteointegration of a titanium (Ti) implant with the calcium phosphate cement (CPC) and autograft prostheses by pull-out test and histological examination. Stems of sixty Ti cylinders were bilaterally inserted into femoral medullary canals in 30 rabbits at the 1st, 4th, 12th, 26th and 70th postoperative weeks. The bone autograft and CPC were filled into the pre-trimmed bone marrow cavity with a polymethyl methacrylate retarder in the distal end, and then a Ti cylinder was inserted into femurs. The CPC group was significantly (p<0.05) associated with a larger pull-out force at 4th (37%) and 12th (62%) weeks compared to the autograft group. The bone area and the bone-to-implant contact ratios of the CPC groups were significantly higher than that of the autograft groups at early healing stage. The histological exams suggest that the CPC enhanced the earlier bone formation around the implant at a period not longer than 12 weeks postoperation. We conclude that CPC graft has the higher ability to facilitate the osteointegration and stabilize the Ti implant at a relatively early stage than the autograft in vivo.

原文English
頁(從 - 到)1186-1195
頁數10
期刊Journal of the Mechanical Behavior of Biomedical Materials
4
發行號7
DOIs
出版狀態Published - 2011 10月

All Science Journal Classification (ASJC) codes

  • 生物材料
  • 生物醫學工程
  • 材料力學

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