Mechanoregulation of cell function

Yang Kao Wang, Rowena McBeath, Nathan J. Sniadecki, John L. Tan, Dana M. Pirone, Christopher S. Chen

研究成果: Conference contribution

摘要

The binding of cell surface receptors to soluble and insoluble adhesive factors is the principal mechanism by which cells survey their microenvironment and accordingly modulate behaviors such as proliferation, differentiation, migration, and apoptosis. Using microfabrication approaches to engineer cellular microenvironments, we are examining how adhesive and soluble cues cooperate to control basic processes such as endothelial cell proliferation, or the commitment and differentiation of human mesenchymal stem cells to a variety of lineage fates. Here, we describe the approaches we have used to reveal that adhesion appears to exert its effects by modulating mechanochemical signals that regulate actin cytoskeletal tension. This tension appears to be central to driving the lineage commitment process. These studies suggest that mechanical stress generated within cells appears to be a central regulator of cellular function shared among many types of cells.

原文English
主出版物標題Proceedings of the 2005 Summer Bioengineering Conference, 2005 SBC
頁面904-905
頁數2
出版狀態Published - 2005 十二月 1
事件2005 Summer Bioengineering Conference - Vail, CO, United States
持續時間: 2005 六月 222005 六月 26

出版系列

名字Proceedings of the 2005 Summer Bioengineering Conference
2005

Other

Other2005 Summer Bioengineering Conference
國家/地區United States
城市Vail, CO
期間05-06-2205-06-26

All Science Journal Classification (ASJC) codes

  • 工程 (全部)

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