Medial prefrontal cortex and nucleus accumbens core are involved in retrieval of the methamphetamine-associated memory

Chih Yuan Chiang, Chianfang G. Cherng, Yu Ting Lai, Hsin Yi Fan, Jia Ying Chuang, Gour Shenq Kao, Wan Ting Chang, Lung Yu

研究成果: Article同行評審

12 引文 斯高帕斯(Scopus)

摘要

Immunohistochemical Fos staining has proven to be a method to identify the neurons that are activated by stimulation. Although methamphetamine (MA)-conditioned place preference (CPP) memory was long-lasting, how this memory was established and retrieved remained unknown. We used the vehicle- and MA-conditioned environment (including cues and context) to reactivate the MA-CPP memory in mice. In the limbic system, Fos-positive neurons were examined following retrieval of the MA-CPP memory. We demonstrated that the current conditioning procedure produced reliable MA-CPP performance. Moreover, enhanced Fos expressions were found in the medial prefrontal cortex and the core of the nucleus accumbens after reactivation of the MA-CPP memory. Furthermore, familiarity with the environmental cues/context was found to significantly enhance Fos expressions in dorsal striatum and dentate gyrus. Nucleus accumbens shell, basolateral or lateral amygdala, in this regard, did not seem to be involved in retrieval of the MA-CPP memory. These results, taken together, suggest that the medial prefrontal cortex and the core of the nucleus accumbens are anatomical substrates responsible for reactivation of the MA-CPP memory.

原文English
頁(從 - 到)24-30
頁數7
期刊Behavioural Brain Research
197
發行號1
DOIs
出版狀態Published - 2009 一月 30

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

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