Melatonin potentiates 5-HT1A receptor activation in rat hypothalamus and results in hypothermia

Mao Tsun Lin, Jih Ing Chuang

研究成果: Article同行評審

29 引文 斯高帕斯(Scopus)


Effects of melatonin on both thermoregulatory responses and hypothalamic serotonin release were assessed in unanesthetized rats at three different ambient temperatures (Ta). Systemic administration of melatonin (30-120 mg/kg, i.p) caused a decrease in both colonic temperature and hypothalamic serotonin (5-HT) release in rats at both Ta 8 and 22°C. The hypothermia was brought about by a decrease in metabolic rate at Ta 8°C, whereas at Ta 22°C the hypothermia was produced by both a decrease in metabolic rate and an increase in cutaneous temperature. However, in the heat (Ta 31°C), neither thermoregulatory responses nor hypothalamic 5-HT release was affected by the same amount of administered melatonin. The melatonin-induced hypothermia and decreased 5-HT release in the hypothalamus were attenuated by selective depletion of brain 5-HT produced by intracerebroventricular injection of 5,7-dihydroxytryptamine. Furthermore, the melatonin-induced hypothermia was almost completely abolished by treatment with a 5-HT2A receptor agonist (DOI) or a 5-HT1A receptor antagonist [(-)-pindolol]. The data indicate that melatonin potentiates the 5-HT1A receptor activation in the hypothalamus and results in hypothermic effects which can be antagonized by the expected hyperthermic effect of DOI.

頁(從 - 到)14-19
期刊Journal of Pineal Research
出版狀態Published - 2002

All Science Journal Classification (ASJC) codes

  • 內分泌


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