Memantine elicits spinal blockades of motor function, proprioception, and nociception in rats

Yu Wen Chen, Chong Chi Chiu, Kuo Sheng Liu, Ching Hsia Hung, Jhi Joung Wang

研究成果: Article

6 引文 (Scopus)

摘要

Although memantine blocks sodium currents and produces local skin anesthesia, spinal anesthesia with memantine is unknown. The purpose of the study was to evaluate the local anesthetic effect of memantine in spinal anesthesia and its comparison with a widely used local anesthetic lidocaine. After intrathecally injecting the rats with five doses of each drug, the dose-response curves of memantine and lidocaine were constructed. The potencies of the drugs and durations of spinal anesthetic effects on motor function, proprioception, and nociception were compared with those of lidocaine. We showed that memantine produced dose-dependent spinal blockades in motor function, proprioception, and nociception. On a 50% effective dose (ED50) basis, the rank of potency was lidocaine greater than memantine (P < 0.05 for the differences). At the equipotent doses (ED25, ED50, ED75), the block duration produced by memantine was longer than that produced by lidocaine (P < 0.05 for the differences). Memantine, but not lidocaine, displayed more sensory/nociceptive block than motor block. The preclinical data demonstrated that memantine is less potent than lidocaine, whereas memantine produces longer duration of spinal anesthesia than lidocaine. Memantine shows a more sensory-selective action over motor blockade.

原文English
頁(從 - 到)567-574
頁數8
期刊Fundamental and Clinical Pharmacology
29
發行號6
DOIs
出版狀態Published - 2015 十二月 1

指紋

Memantine
Proprioception
Nociception
Lidocaine
Spinal Anesthesia
Local Anesthetics
Anesthetics
Local Anesthesia
Pharmaceutical Preparations
Sodium

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

引用此文

Chen, Yu Wen ; Chiu, Chong Chi ; Liu, Kuo Sheng ; Hung, Ching Hsia ; Wang, Jhi Joung. / Memantine elicits spinal blockades of motor function, proprioception, and nociception in rats. 於: Fundamental and Clinical Pharmacology. 2015 ; 卷 29, 編號 6. 頁 567-574.
@article{294427b586dc49dc949a0c5eb1e03c6c,
title = "Memantine elicits spinal blockades of motor function, proprioception, and nociception in rats",
abstract = "Although memantine blocks sodium currents and produces local skin anesthesia, spinal anesthesia with memantine is unknown. The purpose of the study was to evaluate the local anesthetic effect of memantine in spinal anesthesia and its comparison with a widely used local anesthetic lidocaine. After intrathecally injecting the rats with five doses of each drug, the dose-response curves of memantine and lidocaine were constructed. The potencies of the drugs and durations of spinal anesthetic effects on motor function, proprioception, and nociception were compared with those of lidocaine. We showed that memantine produced dose-dependent spinal blockades in motor function, proprioception, and nociception. On a 50{\%} effective dose (ED50) basis, the rank of potency was lidocaine greater than memantine (P < 0.05 for the differences). At the equipotent doses (ED25, ED50, ED75), the block duration produced by memantine was longer than that produced by lidocaine (P < 0.05 for the differences). Memantine, but not lidocaine, displayed more sensory/nociceptive block than motor block. The preclinical data demonstrated that memantine is less potent than lidocaine, whereas memantine produces longer duration of spinal anesthesia than lidocaine. Memantine shows a more sensory-selective action over motor blockade.",
author = "Chen, {Yu Wen} and Chiu, {Chong Chi} and Liu, {Kuo Sheng} and Hung, {Ching Hsia} and Wang, {Jhi Joung}",
year = "2015",
month = "12",
day = "1",
doi = "10.1111/fcp.12142",
language = "English",
volume = "29",
pages = "567--574",
journal = "Fundamental and Clinical Pharmacology",
issn = "0767-3981",
publisher = "Wiley-Blackwell",
number = "6",

}

Memantine elicits spinal blockades of motor function, proprioception, and nociception in rats. / Chen, Yu Wen; Chiu, Chong Chi; Liu, Kuo Sheng; Hung, Ching Hsia; Wang, Jhi Joung.

於: Fundamental and Clinical Pharmacology, 卷 29, 編號 6, 01.12.2015, p. 567-574.

研究成果: Article

TY - JOUR

T1 - Memantine elicits spinal blockades of motor function, proprioception, and nociception in rats

AU - Chen, Yu Wen

AU - Chiu, Chong Chi

AU - Liu, Kuo Sheng

AU - Hung, Ching Hsia

AU - Wang, Jhi Joung

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Although memantine blocks sodium currents and produces local skin anesthesia, spinal anesthesia with memantine is unknown. The purpose of the study was to evaluate the local anesthetic effect of memantine in spinal anesthesia and its comparison with a widely used local anesthetic lidocaine. After intrathecally injecting the rats with five doses of each drug, the dose-response curves of memantine and lidocaine were constructed. The potencies of the drugs and durations of spinal anesthetic effects on motor function, proprioception, and nociception were compared with those of lidocaine. We showed that memantine produced dose-dependent spinal blockades in motor function, proprioception, and nociception. On a 50% effective dose (ED50) basis, the rank of potency was lidocaine greater than memantine (P < 0.05 for the differences). At the equipotent doses (ED25, ED50, ED75), the block duration produced by memantine was longer than that produced by lidocaine (P < 0.05 for the differences). Memantine, but not lidocaine, displayed more sensory/nociceptive block than motor block. The preclinical data demonstrated that memantine is less potent than lidocaine, whereas memantine produces longer duration of spinal anesthesia than lidocaine. Memantine shows a more sensory-selective action over motor blockade.

AB - Although memantine blocks sodium currents and produces local skin anesthesia, spinal anesthesia with memantine is unknown. The purpose of the study was to evaluate the local anesthetic effect of memantine in spinal anesthesia and its comparison with a widely used local anesthetic lidocaine. After intrathecally injecting the rats with five doses of each drug, the dose-response curves of memantine and lidocaine were constructed. The potencies of the drugs and durations of spinal anesthetic effects on motor function, proprioception, and nociception were compared with those of lidocaine. We showed that memantine produced dose-dependent spinal blockades in motor function, proprioception, and nociception. On a 50% effective dose (ED50) basis, the rank of potency was lidocaine greater than memantine (P < 0.05 for the differences). At the equipotent doses (ED25, ED50, ED75), the block duration produced by memantine was longer than that produced by lidocaine (P < 0.05 for the differences). Memantine, but not lidocaine, displayed more sensory/nociceptive block than motor block. The preclinical data demonstrated that memantine is less potent than lidocaine, whereas memantine produces longer duration of spinal anesthesia than lidocaine. Memantine shows a more sensory-selective action over motor blockade.

UR - http://www.scopus.com/inward/record.url?scp=84983123412&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84983123412&partnerID=8YFLogxK

U2 - 10.1111/fcp.12142

DO - 10.1111/fcp.12142

M3 - Article

C2 - 26301611

AN - SCOPUS:84983123412

VL - 29

SP - 567

EP - 574

JO - Fundamental and Clinical Pharmacology

JF - Fundamental and Clinical Pharmacology

SN - 0767-3981

IS - 6

ER -