Meso-Functionalization of Silk Fibroin by Upconversion Fluorescence and Near Infrared In Vivo Biosensing

Yang Song, Zaifu Lin, Lingqing Kong, Yao Xing, Naibo Lin, Zhisen Zhang, Bing-Hung Chen, Xiang Yang Liu

研究成果: Article

15 引文 (Scopus)

摘要

In biomedical applications, it is very desirable to monitor the in vivo state of implanted devices, i.e., tracking the location, the state, and the interaction between the implanted devices and cell tissues. To achieve this goal, a generic strategy of soft materials meso-functionalization is presented. This is to acquire silk fibroin (SF) materials with added functions, i.e., in vivo bioimaging/sensing. The functionalization is by 3D materials assembly of functional components, lanthanide(Ln)-doped upconversion nanoparticles (UCNPs) on the mesoscopic scale to acquire upconversion fluorescent emission. To implement the meso-functionalization, the surfaces of UCNPs are modified by the hydroxyl groups (OH) from SiO 2 or polyethylene glycol coating layers, which can interact with the carbonyl groups (CO) in SF scaffolds. The functionalized silk scaffolds are further implanted subcutaneously into mice, which allows the silk scaffolds to have fluorescent in vivo bioimaging and other biomedical functions. This material functionalization strategy may lead to the rational design of biomaterials in a more generic way.

原文English
文章編號1700628
期刊Advanced Functional Materials
27
發行號26
DOIs
出版狀態Published - 2017 七月 12

指紋

Fibroins
silk
Silk
Fluorescence
Scaffolds
Infrared radiation
fluorescence
Nanoparticles
Lanthanoid Series Elements
nanoparticles
Biocompatible Materials
Rare earth elements
Biomaterials
Hydroxyl Radical
Polyethylene glycols
mice
glycols
polyethylenes
assembly
Tissue

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

引用此文

Song, Yang ; Lin, Zaifu ; Kong, Lingqing ; Xing, Yao ; Lin, Naibo ; Zhang, Zhisen ; Chen, Bing-Hung ; Liu, Xiang Yang. / Meso-Functionalization of Silk Fibroin by Upconversion Fluorescence and Near Infrared In Vivo Biosensing. 於: Advanced Functional Materials. 2017 ; 卷 27, 編號 26.
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Meso-Functionalization of Silk Fibroin by Upconversion Fluorescence and Near Infrared In Vivo Biosensing. / Song, Yang; Lin, Zaifu; Kong, Lingqing; Xing, Yao; Lin, Naibo; Zhang, Zhisen; Chen, Bing-Hung; Liu, Xiang Yang.

於: Advanced Functional Materials, 卷 27, 編號 26, 1700628, 12.07.2017.

研究成果: Article

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AU - Zhang, Zhisen

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AU - Liu, Xiang Yang

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