Metabolic and colonic microbiota transformation may enhance the bioactivities of dietary polyphenols

Yi Shiou Chiou, Jia Ching Wu, Qingrong Huang, Fereidoon Shahidi, Ying Jan Wang, Chi Tang Ho, Min Hsiung Pan

研究成果: Article同行評審

101 引文 斯高帕斯(Scopus)

摘要

Epidemiological evidences throughout the years have indicated that consumption of phytochemicals may play important functions in the regulation of pathological and normal biological processes. Polyphenols are one of the large and ubiquitous groups of phytochemicals. Dietary polyphenols are naturally present in a wide variety of fruits and vegetables, and potentially contribute to the maintenance of human health. However, growing information has indicated that the bioactive compounds from polyphenols may exert beneficial effects in part by their metabolites. The bioactive metabolites were converted by the gut microflora, liver microsomes and hepatocytes, and identified in intestinal, plasma, feces, and urine after dietary ingestion. Surprisingly, recent studies suggested that many metabolites possess more active biological functions than their precursors. In order to explore the possibilities of metabolites in food bioactive compounds, more clear understanding of the metabolic pathways and the molecular targets responsible for health promotion and diseases prevention are needed. In this review, we first summarize the distribution and beneficial health activities of metabolites from dietary polyphenols. We also discuss the available evidence on the relationship between metabolites bioefficacy and bioavailability of their parent polyphenol compounds. We hope that this knowledge will lead to future research to discover and develop new bioactive compounds as possible chemopreventive agents.

原文English
頁(從 - 到)3-25
頁數23
期刊Journal of Functional Foods
7
發行號1
DOIs
出版狀態Published - 2014

All Science Journal Classification (ASJC) codes

  • 食品科學
  • 醫藥(雜項)
  • 營養與營養學

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