Metabolic events associated with the use of antipsychotics in children, adolescents and young adults: a multinational sequence symmetry study

Kenneth K.C. Man, Shih Chieh Shao, Nathorn Chaiyakunapruk, Piyameth Dilokthornsakul, Kiyoshi Kubota, Junqing Li, Nobuhiro Ooba, Nicole Pratt, Anton Pottegård, Lotte Rasmussen, Elizabeth E. Roughead, Ju Young Shin, Chien Chou Su, Ian C.K. Wong, Yea Huei Kao Yang, Edward Chia Cheng Lai

研究成果: Article同行評審

4 引文 斯高帕斯(Scopus)

摘要

It is known that younger patients treated with antipsychotics are at increased risk of metabolic events; however, it is unknown how this risk varies according to ethnicity, the class of antipsychotic and the specific product used, and by age group. We conducted a multinational sequence symmetry study in Asian populations (Hong Kong, Japan, Korea, Taiwan and Thailand) and non-Asian populations (Australia and Denmark) to evaluate the metabolic events associated with antipsychotics in both Asian and non-Asian populations, for typical and atypical antipsychotics, and by the subgroups of children and adolescents, and young adults. Patients aged 6–30 years newly initiating oral antipsychotic drugs were included. We defined a composite outcome for metabolic events which included dyslipidemia, hypertension and hyperglycemia. We calculated the sequence ratio (SR) by dividing the number of people for whom a medicine for one of the outcome events was initiated within a 12-month period after antipsychotic initiation by the number before antipsychotic initiation. This study included 346,904 antipsychotic initiators across seven countries. Antipsychotic use was associated with an increased risk of composite metabolic events with a pooled adjusted SR (ASR) of 1.22 (95% CI 1.00–1.50). Pooled ASRs were similar between Asian (ASR, 1.22; 95% CI 0.88–1.70) and non-Asian populations (ASR, 1.22; 95% CI 1.04–1.43). The pooled ASR for typical and atypical antipsychotics was 0.98 (95% CI 0.85–1.12) and 1.24 (95% CI 0.97–1.59), respectively. No difference was observed in the relative effect in children and adolescents compared to young adults. The risk of metabolic events associated with antipsychotics use was similar in magnitude in Asian and non-Asian populations despite the marked difference in drug utilization patterns.

原文English
頁(從 - 到)99-120
頁數22
期刊European Child and Adolescent Psychiatry
31
發行號1
DOIs
出版狀態Published - 2022 1月

All Science Journal Classification (ASJC) codes

  • 兒科、圍產兒和兒童健康
  • 發展與教育心理學
  • 精神病學和心理健康

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