Metformin regulates oxLDL-facilitated endothelial dysfunction by modulation of SIRT1 through repressing LOX-1-modulated oxidative signaling

Ching Hsia Hung, Shih Hung Chan, Pei Ming Chu, Huei Chen Lin, Kun Ling Tsai

研究成果: Article

11 引文 (Scopus)

摘要

It is suggested that oxLDL is decisive in the initiation and development of atherosclerotic injuries. The up-regulation of oxidative stress and the generation of ROS act as key modulators in developing pro-atherosclerotic and anti-atherosclerotic processes in the human endothelial wall. In this present study, we confirmed that metformin enhanced SIRT1 and AMPK expression in human umbilical vein endothelial cells (HUVECs). Metformin also inhibited oxLDL-increased LOX-1 expression and oxLDL-collapsed AKT/eNOS levels. However, silencing SIRT1 and AMPK diminished the protective function of metformin against oxidative injuries. These results provide a new insight regarding the possible molecular mechanisms of metformin.

原文English
頁(從 - 到)10773-10787
頁數15
期刊Oncotarget
7
發行號10
DOIs
出版狀態Published - 2016 一月 1

指紋

Metformin
AMP-Activated Protein Kinases
Human Umbilical Vein Endothelial Cells
Wounds and Injuries
Oxidative Stress
Up-Regulation
oxidized low density lipoprotein

All Science Journal Classification (ASJC) codes

  • Oncology

引用此文

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abstract = "It is suggested that oxLDL is decisive in the initiation and development of atherosclerotic injuries. The up-regulation of oxidative stress and the generation of ROS act as key modulators in developing pro-atherosclerotic and anti-atherosclerotic processes in the human endothelial wall. In this present study, we confirmed that metformin enhanced SIRT1 and AMPK expression in human umbilical vein endothelial cells (HUVECs). Metformin also inhibited oxLDL-increased LOX-1 expression and oxLDL-collapsed AKT/eNOS levels. However, silencing SIRT1 and AMPK diminished the protective function of metformin against oxidative injuries. These results provide a new insight regarding the possible molecular mechanisms of metformin.",
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T1 - Metformin regulates oxLDL-facilitated endothelial dysfunction by modulation of SIRT1 through repressing LOX-1-modulated oxidative signaling

AU - Hung, Ching Hsia

AU - Chan, Shih Hung

AU - Chu, Pei Ming

AU - Lin, Huei Chen

AU - Tsai, Kun Ling

PY - 2016/1/1

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