Methodological standards for in vitro models of epilepsy and epileptic seizures. A TASK1-WG4 report of the AES/ILAE Translational Task Force of the ILAE

Joseph V. Raimondo; Uwe Heinemann; Marco de Curtis; Howard P. Goodkin; Chris G. Dulla; Damir Janigro; Akio Ikeda; Chou Ching K. Lin; Premysl Jiruska; Aristea S. Galanopoulou; Christophe Bernard

doi:10.1111/epi.13901

Methodological standards for in vitro models of epilepsy and epileptic seizures. A TASK1-WG4 report of the AES/ILAE Translational Task Force of the ILAE

Joseph V. Raimondo, Uwe Heinemann, Marco de Curtis, Howard P. Goodkin, Chris G. Dulla, Damir Janigro, Akio Ikeda, Chou Ching K. Lin, Premysl Jiruska, Aristea S. Galanopoulou, Christophe Bernard

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研究成果: Article › 同行評審

33 引文斯高帕斯（Scopus）

摘要

In vitro preparations are a powerful tool to explore the mechanisms and processes underlying epileptogenesis and ictogenesis. In this review, we critically review the numerous in vitro methodologies utilized in epilepsy research. We provide support for the inclusion of detailed descriptions of techniques, including often ignored parameters with unpredictable yet significant effects on study reproducibility and outcomes. In addition, we explore how recent developments in brain slice preparation relate to their use as models of epileptic activity.

原文	English
頁（從 - 到）	40-52
頁數	13
期刊	Epilepsia
卷	58
DOIs	https://doi.org/10.1111/epi.13901
出版狀態	Published - 2017 11月

All Science Journal Classification (ASJC) codes

神經內科
神經病學（臨床）

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10.1111/epi.13901

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Raimondo, J. V., Heinemann, U., de Curtis, M., Goodkin, H. P., Dulla, C. G., Janigro, D., Ikeda, A., Lin, C. C. K., Jiruska, P., Galanopoulou, A. S., & Bernard, C. (2017). Methodological standards for in vitro models of epilepsy and epileptic seizures. A TASK1-WG4 report of the AES/ILAE Translational Task Force of the ILAE. Epilepsia, 58, 40-52. https://doi.org/10.1111/epi.13901

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abstract = "In vitro preparations are a powerful tool to explore the mechanisms and processes underlying epileptogenesis and ictogenesis. In this review, we critically review the numerous in vitro methodologies utilized in epilepsy research. We provide support for the inclusion of detailed descriptions of techniques, including often ignored parameters with unpredictable yet significant effects on study reproducibility and outcomes. In addition, we explore how recent developments in brain slice preparation relate to their use as models of epileptic activity.",

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year = "2017",

month = nov,

doi = "10.1111/epi.13901",

language = "English",

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AU - Heinemann, Uwe

AU - de Curtis, Marco

AU - Goodkin, Howard P.

AU - Dulla, Chris G.

AU - Janigro, Damir

AU - Ikeda, Akio

AU - Lin, Chou Ching K.

AU - Jiruska, Premysl

AU - Galanopoulou, Aristea S.

AU - Bernard, Christophe

PY - 2017/11

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ER -

Methodological standards for in vitro models of epilepsy and epileptic seizures. A TASK1-WG4 report of the AES/ILAE Translational Task Force of the ILAE

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