Microfluidic systems for fast and accurate diagnosis of ovarian cancers

Yi Cheng Tsai, Wei Ting Liu, Sheng Po Haung, Wen Bin Lee, Yuan Jhe Chuang, Keng Fu Hsu, Gwo Bin Lee

研究成果: Conference contribution

摘要

Fast and accurate diagnosis of cancer is challenging. Aptamers may serve as promising artificial antibodies for cancer diagnosis. However, in order to screen highly specific and high-Affinity aptamers targeting specific cancer, it requires a series of complex and lengthy procedures. Furthermore, the screened aptamers may require further optimization for recognizing biomarkers associate with cancer. Moreover, further clinical applications for cancer diagnosis such as immunohistochemistry (IHC) staining is a labor-intensive, time-consuming procedure which requires well-Trained personnel for carrying out the tedious process. In this work, we reported our recent progress on utilizing integrated microfluidic systems to tackle the above issues. Customized flow and temperature control modules have been established to carry out a fast and automated continuous aptamer screening process on a microfluidic chip for screening ovarian cancer (OvCa) specific aptamers targeting plasma membranes of tissues. Another integrated microfluidic platform was also developed for performing the whole process of IHC staining including the sample pretreatment of tissue samples. With these approaches, aptamers may be used for recognizing and detecting clinical tissue samples for OvCa.

原文English
主出版物標題Proceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019
發行者Institute of Electrical and Electronics Engineers Inc.
頁面39-43
頁數5
ISBN(電子)9781728116297
DOIs
出版狀態Published - 2019 四月
事件14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019 - Bangkok, Thailand
持續時間: 2019 四月 112019 四月 14

出版系列

名字Proceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019

Conference

Conference14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019
國家Thailand
城市Bangkok
期間19-04-1119-04-14

All Science Journal Classification (ASJC) codes

  • Mechanical Engineering
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Instrumentation

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  • 引用此

    Tsai, Y. C., Liu, W. T., Haung, S. P., Lee, W. B., Chuang, Y. J., Hsu, K. F., & Lee, G. B. (2019). Microfluidic systems for fast and accurate diagnosis of ovarian cancers. 於 Proceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019 (頁 39-43). [8915587] (Proceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NEMS.2019.8915587