Microglia reduce herpes simplex virus 1 lethality of mice with decreased t cell and interferon responses in brains

Meng Shan Tsai, Li Chiu Wang, Hsien Yang Tsai, Yu Jheng Lin, Hua Lin Wu, Shun Fen Tzeng, Sheng Min Hsu, Shun Hua Chen

研究成果: Article同行評審

2 引文 斯高帕斯(Scopus)

摘要

Herpes simplex virus 1 (HSV-1) infects the majority of the human population and can induce encephalitis, which is the most common cause of sporadic, fatal encephalitis. An increase of microglia is detected in the brains of encephalitis patients. The issues regarding whether and how microglia protect the host and neurons from HSV-1 infection remain elusive. Using a murine infection model, we showed that HSV-1 infection on corneas increased the number of microglia to outnumber those of infiltrating leukocytes (macrophages, neutrophils, and T cells) and enhanced microglia activation in brains. HSV-1 antigens were detected in brain neurons, which were surrounded by microglia. Microglia depletion increased HSV-1 lethality of mice with elevated brain levels of viral loads, infected neurons, neuron loss, CD4 T cells, CD8 T cells, neutrophils, interferon (IFN)-β, and IFN-γ. In vitro studies demonstrated that microglia from infected mice reduced virus infectivity. Moreover, microglia induced IFN-β and the signaling pathway of signal transducer and activator of transcription (STAT) 1 to inhibit viral replication and damage of neurons. Our study reveals how microglia protect the host and neurons from HSV-1 infection.

原文English
文章編號12457
期刊International journal of molecular sciences
22
發行號22
DOIs
出版狀態Published - 2021 11月 1

All Science Journal Classification (ASJC) codes

  • 催化
  • 分子生物學
  • 光譜
  • 電腦科學應用
  • 物理與理論化學
  • 有機化學
  • 無機化學

指紋

深入研究「Microglia reduce herpes simplex virus 1 lethality of mice with decreased t cell and interferon responses in brains」主題。共同形成了獨特的指紋。

引用此