摘要
Enterovirus 71 (EV71) was implicated in a widespread outbreak of hand-foot-and-mouth disease (HFMD) across the Asia Pacific area since 1997 and has also been reported sporadically in patients with brain stem encephalitis. Neurogenic shock with pulmonary edema (PE) is a fatal complication of EV71 infection. Among inotropic agents, milrinone is selected as a therapeutic agent for EV71- induced PE due to its immunopathogenesis. Milrinone is a type III phosphodiesterase inhibitor that has both inotropic and vasodilator effects. Its clinical efficacy has been shown by modulating inflammation, reducing sympathetic over-activity, and improving survival in patients with EV71-associated PE. Milrinone exhibits immunoregulatory and anti-inflammatory effects in the management of systemic inflammatory responses in severe EV71 infection.
| 原文 | English |
|---|---|
| 文章編號 | 82 |
| 期刊 | Frontiers in Pharmacology |
| 卷 | 7 |
| 發行號 | MAR |
| DOIs | |
| 出版狀態 | Published - 2016 三月 29 |
指紋
All Science Journal Classification (ASJC) codes
- Pharmacology
- Pharmacology (medical)
引用此文
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Milrinone in enterovirus 71 brain stem encephalitis. / Wang, Shih Min.
於: Frontiers in Pharmacology, 卷 7, 編號 MAR, 82, 29.03.2016.研究成果: Short survey
TY - JOUR
T1 - Milrinone in enterovirus 71 brain stem encephalitis
AU - Wang, Shih Min
PY - 2016/3/29
Y1 - 2016/3/29
N2 - Enterovirus 71 (EV71) was implicated in a widespread outbreak of hand-foot-and-mouth disease (HFMD) across the Asia Pacific area since 1997 and has also been reported sporadically in patients with brain stem encephalitis. Neurogenic shock with pulmonary edema (PE) is a fatal complication of EV71 infection. Among inotropic agents, milrinone is selected as a therapeutic agent for EV71- induced PE due to its immunopathogenesis. Milrinone is a type III phosphodiesterase inhibitor that has both inotropic and vasodilator effects. Its clinical efficacy has been shown by modulating inflammation, reducing sympathetic over-activity, and improving survival in patients with EV71-associated PE. Milrinone exhibits immunoregulatory and anti-inflammatory effects in the management of systemic inflammatory responses in severe EV71 infection.
AB - Enterovirus 71 (EV71) was implicated in a widespread outbreak of hand-foot-and-mouth disease (HFMD) across the Asia Pacific area since 1997 and has also been reported sporadically in patients with brain stem encephalitis. Neurogenic shock with pulmonary edema (PE) is a fatal complication of EV71 infection. Among inotropic agents, milrinone is selected as a therapeutic agent for EV71- induced PE due to its immunopathogenesis. Milrinone is a type III phosphodiesterase inhibitor that has both inotropic and vasodilator effects. Its clinical efficacy has been shown by modulating inflammation, reducing sympathetic over-activity, and improving survival in patients with EV71-associated PE. Milrinone exhibits immunoregulatory and anti-inflammatory effects in the management of systemic inflammatory responses in severe EV71 infection.
UR - http://www.scopus.com/inward/record.url?scp=84964636367&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84964636367&partnerID=8YFLogxK
U2 - 10.3389/fphar.2016.00082
DO - 10.3389/fphar.2016.00082
M3 - Short survey
AN - SCOPUS:84964636367
VL - 7
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
SN - 1663-9812
IS - MAR
M1 - 82
ER -