miR-196a enhances neuronal morphology through suppressing RANBP10 to provide neuroprotection in Huntington's disease

Lu Shiun Her, Su Han Mao, Chih Yi Chang, Pei Hsun Cheng, Yu Fan Chang, Han In Yang, Chuan Mu Chen, Shang Hsun Yang

研究成果: Article同行評審

42 引文 斯高帕斯(Scopus)

摘要

MicroRNAs (miRNAs) play important roles in several neurobiological processes, including the development and progression of diseases. Previously, we identified that one specific miRNA, miR-196a, provides neuroprotective effects on Huntington's disease (HD), although the detailed mechanism is still unclear. Based on our bioinformatic analyses, we hypothesize miR-196a might offer neuroprotective functions through improving cytoskeletons of brain cells. Here, we show that miR-196a could enhance neuronal morphology, further ameliorating intracellular transport, synaptic plasticity, neuronal activity, and learning and memory abilities. Additionally, we found that miR-196a could suppress the expression of RAN binding protein 10 (RANBP10) through binding to its 3' untranslated region, and higher expression of RANBP10 exacerbates neuronal morphology and intracellular transport. Furthermore, miR-196a enhances neuronal morphology through suppressing RANBP10 and increasing the ability of β-tubulin polymerization. Most importantly, we observed higher expression of RANBP10 in the brains of HD transgenic mice, and higher expression of RANBP10 might exacerbate the pathological aggregates in HD. Taken together, we provide evidence that enhancement of neuronal morphology through RANBP10 is one of the neuroprotective mechanisms for miR-196a. Since miR-196a has also been reported in other neuronal diseases, this study might offer insights with regard to the therapeutic use of miR-196a in other neuronal diseases.

原文English
頁(從 - 到)2452-2462
頁數11
期刊Theranostics
7
發行號9
DOIs
出版狀態Published - 2017

All Science Journal Classification (ASJC) codes

  • 醫藥(雜項)
  • 藥理學、毒理學和藥劑學(雜項)

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