miR-21 upregulation exacerbates pressure overload-induced cardiac hypertrophy in aged hearts

Wei Ting Chang, Jhih Yuan Shih, Yu Wen Lin, Tzu Ling Huang, Zhih Cherng Chen, Chi Long Chen, Jan Show Chu, Ping Yen Liu

研究成果: Article同行評審

5 引文 斯高帕斯(Scopus)

摘要

Young and aging hearts undergo different remodeling post pressure overload, but the regulator that determines responses to pressure overload at different ages remains unknown. With an angiotensin II (Ang II)-induced hypertensive model, miR-21 knockout mice (miR-21−/−) were observed regarding the effects of miR-21 on hypertension-induced cardiac remodeling in young (12 week-old) and old (50 week-old) mice. Although the aged heart represented a more significant hypertrophy and was associated with a higher expression of miR-21, Ang II-induced cardiac hypertrophy was attenuated in miR-21−/− mice. Upon results of cardiac-specific arrays in miR-21-overexpressing cardiomyocytes, we found a significant downregulation of S100a8. In both in vitro and in vivo models, miR-21/S100a8/NF-κB/NFAT pathway was observed to be associated with pressure overload-induced hypertrophic remodeling in aged hearts. To further investigate whether circulating miR-21 could be a biomarker reflecting the aged associated cardiac remodeling, we prospectively collected clinical and echocardiographic information of patients at young (<65 y/o) and old ages (≥65 y/o) with and without hypertension. Among 108 patients, aged subjects presented with a significantly higher expression of circulating miR-21, which was positively correlated with left ventricular wall thickness. Collectively, miR-21 was associated with a prominently hypertrophic response in aged hearts under pressure overload.

原文English
頁(從 - 到)5925-5945
頁數21
期刊Aging
14
發行號14
DOIs
出版狀態Published - 2022

All Science Journal Classification (ASJC) codes

  • 老化
  • 細胞生物學

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