Mir-29a-3p/thbs2 axis regulates pah-induced cardiac fibrosis

Chih Hsin Hsu, I. Fan Liu, Hsuan Fu Kuo, Chia Yang Li, Wei Shiung Lian, Chia Yuan Chang, Yung Hsiang Chen, Wei Lun Liu, Chi Yu Lu, Yu Ru Liu, Tzu Chieh Lin, Tsung Ying Lee, Chi Yuan Huang, Chong Chao Hsieh, Po Len Liu

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

Pulmonary artery hypertension (PAH) pathology involves extracellular matrix (ECM) remodeling in cardiac tissues, thus promoting cardiac fibrosis progression. miR-29a-3p reportedly inhibits lung progression and liver fibrosis by regulating ECM protein expression; however, its role in PAH-induced fibrosis remains unclear. In this study, we aimed to investigate the role of miR-29a-3p in cardiac fibrosis progression in PAH and its influence on ECM protein thrombospondin-2 (THBS2) expression. The diagnostic and prognostic values of miR-29a-3p and THBS2 in PAH were evaluated. The expressions and effects of miR-29a-3p and THBS2 were assessed in cell culture, monocrotaline-induced PAH mouse model, and patients with PAH. The levels of circulating miR-29a-3p and THBS2 in patients and mice with PAH decreased and increased, respectively. miR-29a-3p directly targets THBS2 and regulates THBS2 expression via a direct anti-fibrotic effect on PAH-induced cardiac fibrosis. The circulating levels of miR-29a-3p and THBS2 were correlated with PAH diagnostic parameters, suggesting their independent prognostic value. miR-29a-3p targeted THBS2 expression via a direct anti-fibrotic effect on PAH-induced cardiac fibrosis, indicating miR-29a-3p acts as a messenger with promising therapeutic effects.

原文English
文章編號10574
期刊International journal of molecular sciences
22
發行號19
DOIs
出版狀態Published - 2021 10月 1

All Science Journal Classification (ASJC) codes

  • 催化
  • 分子生物學
  • 光譜
  • 電腦科學應用
  • 物理與理論化學
  • 有機化學
  • 無機化學

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