Miracle fruit (Synsepalum dulcificum) exhibits as a novel anti-hyperuricaemia agent

Yeu Ching Shi, Kai Sian Lin, Yi Fen Jhai, Bao Hong Lee, Yifan Han, Zhibin Cui, Wei Hsuan Hsu, She Ching Wu

研究成果: Article同行評審

17 引文 斯高帕斯(Scopus)

摘要

Miracle fruit (Synsepalum dulcificum) belongs to the Sapotaceae family. It can change flavors on taste buds, transforming acidic tastes to sweet. We evaluated various miracle fruit extracts, including water, butanol, ethyl acetate (EA), and hexane fractions, to determine its antioxidant effects. These extracts isolated from miracle fruit exerted potential for reduction of uric acid and inhibited xanthine oxidase activity in vitro and in monosodiumurate (MSU)-treated RAW264.7 macrophages. Moreover, we also found that the butanol extracts of miracle fruit attenuated oxonic acid potassium salt-induced hyperuricaemia in ICR mice by lowering serum uric acid levels and activating hepatic xanthine oxidase. These effects were equal to those of allopurinol, suggesting that the butanol extract of miracle fruit could be developed as a novel anti-hyperuricaemia agent or health food.

原文English
文章編號140
期刊Molecules
21
發行號2
DOIs
出版狀態Published - 2016 二月

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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