Mobilization of endothelial progenitor cells following creation of arteriovenous access in patients with end-stage renal disease

Jun Neng Roan, Chwan Yau Luo, Mang Da Tsai, I. Shuan Wu, Shih Wei Chang, Chien Chi Huang, Yau Sheng Tsai, Chen Fuh Lam

研究成果: Article同行評審

3 引文 斯高帕斯(Scopus)

摘要

Background: A patent arteriovenous (AV) fistula induces activation of regional vascular endothelium and vascular shear force. Shear stress is an important physiological force in mobilizing endothelial progenitor cells (EPCs). This study aimed to explore the perioperative changes of circulating EPC levels for patients who require hemodialysis and underwent radiocephalic fistula operation. Methods: This prospective cohort study included patients who received a radiocephalic fistula surgery when they were between 25 and 65 years of age. The subjects were followed for 90 days postoperatively for any stenotic events or immaturity of the fistula. Blood samples were obtained on the day before surgery and at postoperation day (POD) 3 and 30. CD133+/KDR+ cells, defined as EPCs, were analyzed using flow cytometry. Blood flow of the fistula was followed on POD 3 and 30. Results : A total of 30 patients were enrolled in the study from July 2009 to December 2011. One patient dropped out of the study and seven patients developed a stenotic (or immature) AV fistula (7/29, 24.1%). There were positive linear relationships between EPC numbers and shear rate postoperatively, which were more significant on POD 30. In addition, postoperative mobilization of EPCs was significantly higher in patients who developed a stenotic fistula than those without. Conclusions : The mobilization of circulating EPCs correlated with a compromised arteriovenous fistula. The biological significance of increased EPC numbers need to be determined in future studies.

原文English
頁(從 - 到)24-32
頁數9
期刊Acta Cardiologica Sinica
31
發行號1
DOIs
出版狀態Published - 2015 1月 1

All Science Journal Classification (ASJC) codes

  • 心臟病學與心血管醫學

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