Modification of 2,2′,2″-tripyridine-induced tremor in mice by serotonergic agonists and antagonists and benzodiazepines

Lin-Shiau Shoei-Yn Lin-Shiau, Hsu Kuei-Sen Hsu

研究成果: Article同行評審

4 引文 斯高帕斯(Scopus)

摘要

The administration of 2,2′,2″-tripyridine produced generalized tremor, myoclonus, and hindlimb abduction, similar to the "5-hydroxytryptamine (5-HT) syndrome," in mice. Pretreatment with mianserin, cyproheptadine, methysergide, or metergoline ameliorated, whereas 5-hydroxytryptophan (5-HTP), 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), or 8-hydroxy-2-[di-n-propylamino]tetraline hydrobromide (8-OH-DPAT) augmented the 2,2′,2″-tripyridine-induced tremor. Furthermore, diazepam and flunitrazepam exhibited a dose-dependent protection against 2,2′,2″-tripyridine-induced tremor in mice, but pentobarbital only had a slightly protective effect. The inhibitory effects of diazepam and flunitrazepam on the 2,2′,2″-tripyridine-induced tremor were potentiated in mice pretreated with p-chlorophenylalanine (PCPA). These observations suggest a serotonin-mediated action of 2,2′,2″-tripyridine in its tremor action and that the benzodiazepine agonist attenuation of the 2,2′,2″-tripyridine-induced tremor is probably mediated through the GABAergic inhibition of serotonergic neurons.

原文English
頁(從 - 到)665-670
頁數6
期刊Pharmacology, Biochemistry and Behavior
48
發行號3
DOIs
出版狀態Published - 1994 七月

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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