Modulation of innate immune toxicity by silver nanoparticle exposure and the preventive effects of pterostilbene

Rong Jane Chen, Chiao Ching Huang, Rosita Pranata, Yu Hsuan Lee, Yu Ying Chen, Yuan Hua Wu, Ying Jan Wang

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

Silver nanoparticles pose a potential risk to ecosystems and living organisms due to their widespread use in various fields and subsequent gradual release into the environment. Only a few studies have investigated the effects of silver nanoparticles (AgNPs) toxicity on immunological functions. Furthermore, these toxic effects have not been fully explored. Recent studies have indicated that zebrafish are considered a good alternative model for testing toxicity and for evaluating immunological toxicity. Therefore, the purpose of this study was to investigate the toxicity effects of AgNPs on innate immunity using a zebrafish model and to investigate whether the natural com-pound pterostilbene (PTE) could provide protection against AgNPs‐induced immunotoxicity. Wild type and neutrophil‐ and macrophage‐transgenic zebrafish lines were used in the experiments. The results indicated that the exposure to AgNPs induced toxic effects including death, malformation and the innate immune toxicity of zebrafish. In addition, AgNPs affect the number and function of neutrophils and macrophages. The expression of immune‐related cytokines and chemokines was also affected. Notably, the addition of PTE could activate immune cells and promote their accumu-lation in injured areas in zebrafish, thereby reducing the damage caused by AgNPs. In conclusion, AgNPs may induce innate immune toxicity and PTE could ameliorate this toxicity.

原文English
文章編號2536
頁(從 - 到)1-19
頁數19
期刊International journal of molecular sciences
22
發行號5
DOIs
出版狀態Published - 2021 三月 1

All Science Journal Classification (ASJC) codes

  • 催化
  • 分子生物學
  • 光譜
  • 電腦科學應用
  • 物理與理論化學
  • 有機化學
  • 無機化學

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