Molecular biomarkers and epidemiologic risk assessment

Paul W. Brandt-Rauf, Jiin Chyuan Luo, Tsun Jen Cheng, Chung Li Du, Jung Der Wang, Ramon Rosal, Tamara Do, Marie Jeanne Marion

研究成果: Review article

2 引文 (Scopus)

摘要

The use of molecular biomarkers in epidemiologic studies has been advanced as a way to improve risk assessments for occupational and environmental exposures to toxic agents. We have used the detection of two cancer-related, molecular biomarkers of vinyl chloride exposure (mutant ras-p21 and mutant p53) to examine workers with equivalent cumulative exposures that would be above or below the current permissible workplace exposure limit for vinyl chloride for differences in the presence of these biomarkers. Workers with cumulative exposures above the current permissible exposure limit (equivalent of > 40 ppm-years) have a statistically significantly increased occurrence of both biomarkers in comparison to unexposed controls (p < 10-3). Although workers with cumulative exposures of < 10 ppm-years, i.e., well below the current limit, do not have a statistically significantly increased occurrence of these biomarkers (p > 0.05), workers with cumulative exposures of 10 to 40 ppm-years, i.e., still below the current limit, are found to have a statistically significant increase (p < 0.05). This suggests that the current exposure limit may not be adequately protective and illustrates the potential utility of molecular biomarkers in the refinement of risk assessments for toxic exposures.

原文English
頁(從 - 到)1295-1301
頁數7
期刊Human and Ecological Risk Assessment
8
發行號6
DOIs
出版狀態Published - 2002 十月 1

指紋

Biomarkers
Risk assessment
biomarker
risk assessment
Vinyl Chloride
Poisons
Proto-Oncogene Proteins p21(ras)
Environmental Exposure
Occupational Exposure
Workplace
chloride
Epidemiologic Studies
exposure
workplace
cancer
Neoplasms

All Science Journal Classification (ASJC) codes

  • Ecological Modelling
  • Pollution
  • Health, Toxicology and Mutagenesis

引用此文

Brandt-Rauf, P. W., Luo, J. C., Cheng, T. J., Du, C. L., Wang, J. D., Rosal, R., ... Marion, M. J. (2002). Molecular biomarkers and epidemiologic risk assessment. Human and Ecological Risk Assessment, 8(6), 1295-1301. https://doi.org/10.1080/20028091057367
Brandt-Rauf, Paul W. ; Luo, Jiin Chyuan ; Cheng, Tsun Jen ; Du, Chung Li ; Wang, Jung Der ; Rosal, Ramon ; Do, Tamara ; Marion, Marie Jeanne. / Molecular biomarkers and epidemiologic risk assessment. 於: Human and Ecological Risk Assessment. 2002 ; 卷 8, 編號 6. 頁 1295-1301.
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Brandt-Rauf, PW, Luo, JC, Cheng, TJ, Du, CL, Wang, JD, Rosal, R, Do, T & Marion, MJ 2002, 'Molecular biomarkers and epidemiologic risk assessment', Human and Ecological Risk Assessment, 卷 8, 編號 6, 頁 1295-1301. https://doi.org/10.1080/20028091057367

Molecular biomarkers and epidemiologic risk assessment. / Brandt-Rauf, Paul W.; Luo, Jiin Chyuan; Cheng, Tsun Jen; Du, Chung Li; Wang, Jung Der; Rosal, Ramon; Do, Tamara; Marion, Marie Jeanne.

於: Human and Ecological Risk Assessment, 卷 8, 編號 6, 01.10.2002, p. 1295-1301.

研究成果: Review article

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