Molecular mechanisms of psychostimulant addiction

Jin Chung Chen, Pei Chun Chen, Yao Chang Chiang

研究成果: Review article

51 引文 (Scopus)

摘要

Drug addiction represents a pathological form of neuroplasticity along with the emergence of aberrant behaviors involving a cascade of neurochemical changes mainly in the brain's rewarding circuitry. The aberrant behavioral phenotypes can be assessed by an animal model of drug-induced behavioral sensitization, which is characterized by an initiation stage that is formed in the ventral tegmental area and a behavioral expression stage determined mainly in the nucleus accumbens. Numerous studies during past decades demonstrate that the mesocorticolimbic dopamine pathway plays an essential role in the development of behavioral sensitization. Moreover, a series of cellular signaling pathways and gene expression determine the severity of addictive behaviors. In addition to the well-characterized dopamine D1 receptor-mediated cAMP/protein kinase A up-regulation in the nucleus accumbens, recent reports indicate the cellular mediator dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32) and transcription regulator AFosB are associated with the accumbal PKA pathway to modulate the development of behavioral sensitization. The finding of cAMP-independent and dopamine D 2 receptor-mediated Akt/GSK3 in activation in the nucleus accumbens of behaviorally sensitized animals implies that a signal cascade down-stream of both dopamine D1 and D2 receptors comprises the mainstay of the addiction network. This review outlines the cellular pathways that have been demonstrated to participate in psychostimulant addiction, focused particularly in the nucleus accumbens.

原文English
頁(從 - 到)148-154
頁數7
期刊Chang Gung medical journal
32
發行號2
出版狀態Published - 2009 三月 1

指紋

Nucleus Accumbens
Dopamine D1 Receptors
Dopamine
Dopamine and cAMP-Regulated Phosphoprotein 32
Addictive Behavior
Ventral Tegmental Area
Neuronal Plasticity
Dopamine D2 Receptors
Cyclic AMP-Dependent Protein Kinases
Substance-Related Disorders
Up-Regulation
Animal Models
Phenotype
Gene Expression
Brain
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Medicine(all)

引用此文

Chen, Jin Chung ; Chen, Pei Chun ; Chiang, Yao Chang. / Molecular mechanisms of psychostimulant addiction. 於: Chang Gung medical journal. 2009 ; 卷 32, 編號 2. 頁 148-154.
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Chen, JC, Chen, PC & Chiang, YC 2009, 'Molecular mechanisms of psychostimulant addiction', Chang Gung medical journal, 卷 32, 編號 2, 頁 148-154.

Molecular mechanisms of psychostimulant addiction. / Chen, Jin Chung; Chen, Pei Chun; Chiang, Yao Chang.

於: Chang Gung medical journal, 卷 32, 編號 2, 01.03.2009, p. 148-154.

研究成果: Review article

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