Molecular mimicry between SARS coronavirus spike protein and human protein

Kuo Yuan Hwa, Wan Man Lin, Yung I. Hou, Trai Ming Yeh

研究成果: Conference contribution

4 引文 斯高帕斯(Scopus)

摘要

Molecular mimicry defined as similar structures shared by molecules from dissimilar genes or by their protein products, is a general strategy for pathogens to infect host cells. Therefore, identification of the molecular mimic regions of a pathogen may be helpful to understand the disease. Severe acute respiratory syndrome (SARS) is a new human respiratory infectious disease caused by SARS coronavirus (SARS-CoV). The virus uses the spike (S) protein to interact with the angiotensin converting enzyme 2, the host cell receptor. Our approach is to design a workflow with multiple bioinformatics tools in analyzing the sequence of spike protein of the SARS-CoV in searching its similarity to human proteins. Furthermore, eleven peptides have been synthesized to validate the in silica results.

原文English
主出版物標題Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007
頁面294-298
頁數5
DOIs
出版狀態Published - 2007
事件Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007 - Jeju Island, Korea, Republic of
持續時間: 2007 10月 112007 10月 13

出版系列

名字Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007

Other

OtherFrontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007
國家/地區Korea, Republic of
城市Jeju Island
期間07-10-1107-10-13

All Science Journal Classification (ASJC) codes

  • 電腦科學應用
  • 資訊系統

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