TY - GEN
T1 - Molecular mimicry between SARS coronavirus spike protein and human protein
AU - Hwa, Kuo Yuan
AU - Lin, Wan Man
AU - Hou, Yung I.
AU - Yeh, Trai Ming
PY - 2007
Y1 - 2007
N2 - Molecular mimicry defined as similar structures shared by molecules from dissimilar genes or by their protein products, is a general strategy for pathogens to infect host cells. Therefore, identification of the molecular mimic regions of a pathogen may be helpful to understand the disease. Severe acute respiratory syndrome (SARS) is a new human respiratory infectious disease caused by SARS coronavirus (SARS-CoV). The virus uses the spike (S) protein to interact with the angiotensin converting enzyme 2, the host cell receptor. Our approach is to design a workflow with multiple bioinformatics tools in analyzing the sequence of spike protein of the SARS-CoV in searching its similarity to human proteins. Furthermore, eleven peptides have been synthesized to validate the in silica results.
AB - Molecular mimicry defined as similar structures shared by molecules from dissimilar genes or by their protein products, is a general strategy for pathogens to infect host cells. Therefore, identification of the molecular mimic regions of a pathogen may be helpful to understand the disease. Severe acute respiratory syndrome (SARS) is a new human respiratory infectious disease caused by SARS coronavirus (SARS-CoV). The virus uses the spike (S) protein to interact with the angiotensin converting enzyme 2, the host cell receptor. Our approach is to design a workflow with multiple bioinformatics tools in analyzing the sequence of spike protein of the SARS-CoV in searching its similarity to human proteins. Furthermore, eleven peptides have been synthesized to validate the in silica results.
UR - http://www.scopus.com/inward/record.url?scp=49349108749&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=49349108749&partnerID=8YFLogxK
U2 - 10.1109/FBIT.2007.108
DO - 10.1109/FBIT.2007.108
M3 - Conference contribution
AN - SCOPUS:49349108749
SN - 0769529992
SN - 9780769529998
T3 - Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007
SP - 294
EP - 298
BT - Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007
T2 - Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007
Y2 - 11 October 2007 through 13 October 2007
ER -