Monoclonality and cytogenetic abnormalities in hyaline vascular Castleman disease

Kung Chao Chang, Yu Chu Wang, Liang Yi Hung, Wan Ting Huang, Jen Hui Tsou, Dan M Jones, Hsiang Lin Song, Yu Min Yeh, Lin Yuan Kao, L. Jeffrey Medeiros

研究成果: Article

32 引文 (Scopus)

摘要

Hyaline vascular Castleman disease is traditionally regarded as a reactive hyperplastic process. Occasional cases, however, have been reported with cytogenetic anomalies bringing this concept into question. In this study, we used conventional and methylation-specific polymerase chain reaction methods to assess the human androgen receptor α (HUMARA) gene in 29 female patients with hyaline vascular Castleman disease and compared the results with three cases of plasma cell Castleman disease and 20 cases of age-matched lymphoid hyperplasia. We also assessed for immunoglobulin gene and T-cell receptor gene rearrangements, and conventional cytogenetic analysis was performed in three cases of hyaline vascular Castleman disease. In cases with informative results, conventional and methylation-specific human androgen receptor α gene analyses yielded a monoclonal pattern in 10 of 19 (53%) and 17 of 23 (74%) cases of hyaline vascular Castleman disease, respectively. A monoclonal pattern was also detected in three cases of plasma cell Castleman disease but not in cases of lymphoid hyperplasia. The frequency of monoclonality was higher for lesions >5 cm in size (100%) and for the stromal-rich variant (91%). Cytogenetic abnormalities in stromal cells were revealed in two cases of hyaline vascular Castleman disease and no cases showed monoclonal immunoglobulin or T-cell receptor gene rearrangements. Follow-up data showed persistent disease in 4 of 23 (17%) patients. We conclude that hyaline vascular Castleman disease is often a monoclonal proliferation, most likely of lymph node stromal cells.

原文English
頁(從 - 到)823-831
頁數9
期刊Modern Pathology
27
發行號6
DOIs
出版狀態Published - 2014 六月

指紋

Giant Lymph Node Hyperplasia
Hyalin
Vascular Diseases
Chromosome Aberrations
T-Lymphocyte Gene Rearrangement
T-Cell Receptor Genes
Stromal Cells
Plasma Cells
Methylation
Hyperplasia
Immunoglobulin Genes
Cytogenetic Analysis
Cytogenetics
Genes
Immunoglobulins
Lymph Nodes
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

引用此文

Chang, Kung Chao ; Wang, Yu Chu ; Hung, Liang Yi ; Huang, Wan Ting ; Tsou, Jen Hui ; M Jones, Dan ; Song, Hsiang Lin ; Yeh, Yu Min ; Kao, Lin Yuan ; Medeiros, L. Jeffrey. / Monoclonality and cytogenetic abnormalities in hyaline vascular Castleman disease. 於: Modern Pathology. 2014 ; 卷 27, 編號 6. 頁 823-831.
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abstract = "Hyaline vascular Castleman disease is traditionally regarded as a reactive hyperplastic process. Occasional cases, however, have been reported with cytogenetic anomalies bringing this concept into question. In this study, we used conventional and methylation-specific polymerase chain reaction methods to assess the human androgen receptor α (HUMARA) gene in 29 female patients with hyaline vascular Castleman disease and compared the results with three cases of plasma cell Castleman disease and 20 cases of age-matched lymphoid hyperplasia. We also assessed for immunoglobulin gene and T-cell receptor gene rearrangements, and conventional cytogenetic analysis was performed in three cases of hyaline vascular Castleman disease. In cases with informative results, conventional and methylation-specific human androgen receptor α gene analyses yielded a monoclonal pattern in 10 of 19 (53{\%}) and 17 of 23 (74{\%}) cases of hyaline vascular Castleman disease, respectively. A monoclonal pattern was also detected in three cases of plasma cell Castleman disease but not in cases of lymphoid hyperplasia. The frequency of monoclonality was higher for lesions >5 cm in size (100{\%}) and for the stromal-rich variant (91{\%}). Cytogenetic abnormalities in stromal cells were revealed in two cases of hyaline vascular Castleman disease and no cases showed monoclonal immunoglobulin or T-cell receptor gene rearrangements. Follow-up data showed persistent disease in 4 of 23 (17{\%}) patients. We conclude that hyaline vascular Castleman disease is often a monoclonal proliferation, most likely of lymph node stromal cells.",
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Chang, KC, Wang, YC, Hung, LY, Huang, WT, Tsou, JH, M Jones, D, Song, HL, Yeh, YM, Kao, LY & Medeiros, LJ 2014, 'Monoclonality and cytogenetic abnormalities in hyaline vascular Castleman disease', Modern Pathology, 卷 27, 編號 6, 頁 823-831. https://doi.org/10.1038/modpathol.2013.202

Monoclonality and cytogenetic abnormalities in hyaline vascular Castleman disease. / Chang, Kung Chao; Wang, Yu Chu; Hung, Liang Yi; Huang, Wan Ting; Tsou, Jen Hui; M Jones, Dan; Song, Hsiang Lin; Yeh, Yu Min; Kao, Lin Yuan; Medeiros, L. Jeffrey.

於: Modern Pathology, 卷 27, 編號 6, 06.2014, p. 823-831.

研究成果: Article

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AU - Yeh, Yu Min

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AU - Medeiros, L. Jeffrey

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AB - Hyaline vascular Castleman disease is traditionally regarded as a reactive hyperplastic process. Occasional cases, however, have been reported with cytogenetic anomalies bringing this concept into question. In this study, we used conventional and methylation-specific polymerase chain reaction methods to assess the human androgen receptor α (HUMARA) gene in 29 female patients with hyaline vascular Castleman disease and compared the results with three cases of plasma cell Castleman disease and 20 cases of age-matched lymphoid hyperplasia. We also assessed for immunoglobulin gene and T-cell receptor gene rearrangements, and conventional cytogenetic analysis was performed in three cases of hyaline vascular Castleman disease. In cases with informative results, conventional and methylation-specific human androgen receptor α gene analyses yielded a monoclonal pattern in 10 of 19 (53%) and 17 of 23 (74%) cases of hyaline vascular Castleman disease, respectively. A monoclonal pattern was also detected in three cases of plasma cell Castleman disease but not in cases of lymphoid hyperplasia. The frequency of monoclonality was higher for lesions >5 cm in size (100%) and for the stromal-rich variant (91%). Cytogenetic abnormalities in stromal cells were revealed in two cases of hyaline vascular Castleman disease and no cases showed monoclonal immunoglobulin or T-cell receptor gene rearrangements. Follow-up data showed persistent disease in 4 of 23 (17%) patients. We conclude that hyaline vascular Castleman disease is often a monoclonal proliferation, most likely of lymph node stromal cells.

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