Month of birth and the risk of narcolepsy: A systematic review and meta-analysis

Chih Wei Hsu, Ping Tao Tseng, Yu Kang Tu, Pao Yen Lin, Liang Jen Wang, Chi Fa Hung, Yao Hsu Yang, Hung Yu Kao, Chin Bin Yeh, Hsiao Ching Lai, Tien Yu Chen

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

Study Objectives: The aim of this study is to evaluate the relationship between the month of birth (MOB) and the risk of narcolepsy. Methods: We conducted a systematic review of the electronic databases PubMed, Embase, and Cochrane CENTRAL from their inception to September 30, 2021. We also added data on narcolepsy from the National Health Insurance Research Database in Taiwan. Then we extracted the relative risk (RR) ratios of narcolepsy in each month of birth to those of the general population and transformed them from MOB to season. A random-effects model was used to calculate pooled RR ratios from the meta-analysis and 95% confidence interval (CI). Results: The meta-analysis analyzed 7 studies and included 3,776 patients from 8 areas (Canada, China, France, Germany, Hong Kong, Netherlands, Taiwan, and United States). The RR ratio was highest in March (1.11; 95% CI, 0.99–1.26) and August (1.11; 95% CI, 0.98–1.26) and lowest in April (0.90; 95% CI, 0.78–1.03). However, none of the MOBs reached statistical significance. Moreover, the narcolepsy risk patterns on the 3 continents (Asia, Europe, and North America) were different. In North America, the highest and lowest significant risks were found in March (1.47; 95% CI, 1.20–1.79) and September (0.75; 95% CI, 0.56–0.99). In Asia, the lowest notable risk was in April (0.80; 95% CI, 0.66–0.97). In Europe, the risk of narcolepsy was not significantly related to any MOB. In terms of seasons, only spring MOBs in North America had a significantly higher risk (1.21; 95% CI, 1.06–1.38). Conclusions: The findings indicated that the risk of narcolepsy and MOB differed across the 3 continents. This study indicates the important role of environmental factors in narcolepsy.

原文English
頁(從 - 到)1113-1120
頁數8
期刊Journal of Clinical Sleep Medicine
18
發行號4
DOIs
出版狀態Published - 2022 4月 1

All Science Journal Classification (ASJC) codes

  • 神經病學(臨床)
  • 神經內科
  • 肺和呼吸系統醫學

指紋

深入研究「Month of birth and the risk of narcolepsy: A systematic review and meta-analysis」主題。共同形成了獨特的指紋。

引用此