More than an “inverted-U”? An exploratory study of the association between the catechol-o-methyltransferase gene polymorphism and executive functions in Parkinson’s disease

Yi Jia Fang, Chun Hsiang Tan, Shao Ching Tu, Chien Yu Liu, Rwei Ling Yu

研究成果: Article同行評審

10 引文 斯高帕斯(Scopus)

摘要

Executive dysfunction is common in Parkinson’s disease (PD) patients. The catechol-O-met hyltransferase (COMT) Val158Met polymorphism has been proposed to affect executive functions (EFs) in the prefrontal cortex. The present study attempted to explore the influence of the COMT polymorphism on EFs in patients with PD. Fifty-four PD patients were recruited and underwent neuropsychological assessments for three core EFs. The COMT polymorphism was genotyped using the TaqMan SNP Genotyping Assay. Participants were divided into three study groups: Val homozygotes, heterozygotes, and Met homozygotes. The three COMT genotype groups had significantly different performances in set-shifting [χ 2 (2, 54) = 9.717, p = 0.008] and working memory tasks [χ 2 (2, 54) = 7.806, p = 0.020]. Post-hoc analyses revealed that PD Val homozygotes performed significantly poorer in the set-shifting task than did either the PD Met homozygotes (z = -2.628, p = 0.009) or PD heterozygotes (z = -2.212, p = 0.027). Our explorative results suggest that the putative level of prefrontal dopamine influenced set-shifting through a “cane-shaped” dopamine level-response relationship. Our results have clinical implications, which may influence PD treatment with dopamine in the future because the optimal dopamine level to maximize EFs may vary based on the clinical course and COMT polymorphism status. Further study recruiting a larger number of participants is needed to confirm our preliminary findings.

原文English
文章編號e0214146
期刊PloS one
14
發行號3
DOIs
出版狀態Published - 2019 3月

All Science Journal Classification (ASJC) codes

  • 多學科

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