Moxifloxacin-associated neutropenia in a cirrhotic elderly woman with lower extremity cellulitis

Chia Ming Chang, Nan Yao Lee, Hsin Chun Lee, I. Wen Lee, Chi Jung Wu, Yu Shiuan Lin, Wen Chien Ko

研究成果: Article同行評審

11 引文 斯高帕斯(Scopus)

摘要

OBJECTIVE: To report a case of moxifloxacin-associated neutropenia in a cirrhotic patient with cellulitis. CASE SUMMARY: A 77-year-old cirrhotic woman developed cellulitis of the right leg, with a nadir white blood cell (WBC) count of 1.5 × 103/μL and absolute neutrophil count (ANC) of 0.345 × 103/μL, which occurred after 5 days of moxifloxacin therapy. Moxifloxacin was switched to cefixime and neutropenia resolved 2 days after the withdrawal of moxifloxacin. DISCUSSION: Cases of neutropenia related to fluoroquinolones have rarely been reported in the literature, and neutropenia associated with moxifloxacin has not been described before. Because of the temporal relationship between moxifloxacin administration and the development of neutropenia in our patient, as well as the relationship between drug withdrawal and improvement in WBC count and ANC, moxifloxacin-associated neutropenia was suspected. This reaction was categorized as probable according to the Naranjo probability scale. CONCLUSIONS: We report the first case of moxifloxacin- associated neutropenia. Although such an adverse reaction is rare, clinicians should be aware of this potential complication of moxifloxacin therapy.

原文English
頁(從 - 到)580-583
頁數4
期刊Annals of Pharmacotherapy
42
發行號4
DOIs
出版狀態Published - 2008 4月

All Science Journal Classification (ASJC) codes

  • 藥學(醫學)

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