Multicentric reticulohistiocytosis without arthritis successfully treated with systemic corticosteroids - A case report and literature review

研究成果: Review article

摘要

A 46-year-old male presented with a 2-month history of multiple red papules on the cheeks and extremities without mucosal involvement or arthritis. There were only some lesions on the dorsal hands without periungual involvement. Biopsy of a skin lesion showed a dermal infiltrate consisting of mononuclear and multinucleated histiocytes with granular "ground glass"-like cytoplasm. These histiocytes were CD68-positive, and S-100 protein and CD30 negative in immunohistochemical studies. The diagnosis of multicentric reticulohistiocytosis without arthritis was made. Laboratory data were within normal limits except mild hypercholesterolemia and hypertriglyceridemia. A survey for internal malignancy showed negative results. The skin lesions responded to prednisolone 0.5 mg/kg daily. The dose was tapered gradually; the cutaneous lesions almost completely resolved after 15 weeks of treatment. Whether multicentric reticulohistiocytosis without arthritis is a subtype with better response to treatment remains to be confirmed by more clinical observation, but systemic corticosteroids may be tried first before starting other immunosuppressive or cytotoxic drugs.

原文English
頁(從 - 到)119-122
頁數4
期刊Dermatologica Sinica
24
發行號2
出版狀態Published - 2006 六月 1

指紋

Arthritis
Adrenal Cortex Hormones
Skin
Histiocytes
S100 Proteins
Cheek
Hypertriglyceridemia
Immunosuppressive Agents
Prednisolone
Hypercholesterolemia
Glass
Cytoplasm
Extremities
Hand
Observation
Biopsy
Pharmaceutical Preparations
Neoplasms

All Science Journal Classification (ASJC) codes

  • Dermatology

引用此文

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N2 - A 46-year-old male presented with a 2-month history of multiple red papules on the cheeks and extremities without mucosal involvement or arthritis. There were only some lesions on the dorsal hands without periungual involvement. Biopsy of a skin lesion showed a dermal infiltrate consisting of mononuclear and multinucleated histiocytes with granular "ground glass"-like cytoplasm. These histiocytes were CD68-positive, and S-100 protein and CD30 negative in immunohistochemical studies. The diagnosis of multicentric reticulohistiocytosis without arthritis was made. Laboratory data were within normal limits except mild hypercholesterolemia and hypertriglyceridemia. A survey for internal malignancy showed negative results. The skin lesions responded to prednisolone 0.5 mg/kg daily. The dose was tapered gradually; the cutaneous lesions almost completely resolved after 15 weeks of treatment. Whether multicentric reticulohistiocytosis without arthritis is a subtype with better response to treatment remains to be confirmed by more clinical observation, but systemic corticosteroids may be tried first before starting other immunosuppressive or cytotoxic drugs.

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