Multiple risk factors of hepatocellular carcinoma: A cohort study of 13 737 male adults in Taiwan

C. ‐J CHEN, M. ‐W YU, C. ‐J WANG, H. ‐Y HUANG, W. ‐C LIN

研究成果: Article

31 引文 (Scopus)

摘要

In order to explore multiple risk factors of hepatocellular carcinoma (HCC), a total of 13 737 male adult residents in 12 townships were studied for an average follow‐up period of 5.2 years. Sociodemographic characteristics, history of cigarette smoking and alcohol drinking, dietary habits, as well as personal and familial history of chronic liver diseases were obtained through standardized interviews based on structured questionnaires at the recruitment. Blood samples were also collected from 9688 (71%) study subjects and examined for the hepatitis B surface antigen (HBsAg). A total of 60 new HCC cases occurred giving an incidence rate of 83.3 per 100 000 person‐years. Cox's proportional hazards models were used to analyse multiple risk factors of HCC. In addition the HBsAg carrier status which showed a multivariate‐adjusted relative risk of 17.0, cumulative cigarette smoking, alcohol drinking quantity, vegetarian habit and low vegetable consumption were associated with the development of HCC. The multivariate‐adjusted relative risk was 1.8 for those who smoked 26 or more pack‐years of cigarettes compared with non‐smokers, 3.1 for those who drank alcohol 50 mL or more per day compared with those who were non‐drinkers or drank less than 50 mL per day, 2.5 for vegetarians compared with non‐vegetarians, as well as 4.6 and 2.6, respectively, for those who had a weekly vegetable consumption frequency of less than two meals and two to five meals compared with those who had a frequency of six or more meals.

原文English
頁(從 - 到)S83-S87
期刊Journal of Gastroenterology and Hepatology
8
發行號1 S
DOIs
出版狀態Published - 1993 一月

指紋

Taiwan
Hepatocellular Carcinoma
Cohort Studies
Meals
Hepatitis B Surface Antigens
Alcohol Drinking
Vegetables
Smoking
Feeding Behavior
Proportional Hazards Models
Tobacco Products
Habits
Liver Diseases
Chronic Disease
Alcohols
Interviews
Incidence
Vegetarians

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

引用此文

CHEN, C. ‐J ; YU, M. ‐W ; WANG, C. ‐J ; HUANG, H. ‐Y ; LIN, W. ‐C. / Multiple risk factors of hepatocellular carcinoma : A cohort study of 13 737 male adults in Taiwan. 於: Journal of Gastroenterology and Hepatology. 1993 ; 卷 8, 編號 1 S. 頁 S83-S87.
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Multiple risk factors of hepatocellular carcinoma : A cohort study of 13 737 male adults in Taiwan. / CHEN, C. ‐J; YU, M. ‐W; WANG, C. ‐J; HUANG, H. ‐Y; LIN, W. ‐C.

於: Journal of Gastroenterology and Hepatology, 卷 8, 編號 1 S, 01.1993, p. S83-S87.

研究成果: Article

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