Multiplexed Graphene Quantum Dots with Excitation-Wavelength-Independent Photoluminescence, as Two-Photon Probes, and in Ultraviolet-Near Infrared Bioimaging

Wen Shuo Kuo, Xing Can Shen, Chia Yuan Chang, Hui Fang Kao, Sheng Han Lin, Jiu Yao Wang, Ping Ching Wu

研究成果: Article同行評審

20 引文 斯高帕斯(Scopus)

摘要

In this study, sorted nitrogen-doped graphene quantum dots were prepared and subsequently conjugated with polymers. The synthesized materials exhibited excitation-wavelength-independent photoluminescence emissions ranging from ultraviolet to near-infrared and were 0.9-8.4 nm in size. The materials also exhibited high-photoluminescence quantum yields and excellent two-photon properties. Therefore, in two-photon bioimaging the materials with different emission spectra can be effective two-photon contrast agents. Specific antibodies were used to label organelles in cancer cells and identify nuclear antigens, thereby enabling the simultaneous detection of four targets in cells at a single two-photon excitation wavelength. The sorted nitrogen-doped graphene quantum dot materials were determined to be considerably more advantageous than organic dyes in identifying multiplexed targets, and they can be effective probes in cellular imaging.

原文English
頁(從 - 到)11502-11509
頁數8
期刊ACS nano
14
發行號9
DOIs
出版狀態Published - 2020 9月 22

All Science Journal Classification (ASJC) codes

  • 材料科學(全部)
  • 工程 (全部)
  • 物理與天文學 (全部)

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