Multistage carcinogenesis process as molecular targets in cancer chemoprevention by epicatechin-3-gallate

Min Hsiung Pan, Yi Siou Chiou, Ying-Jan Wang, Chi Tang Ho, Jen Kun Lin

研究成果: Review article

37 引文 (Scopus)

摘要

The consumption of green tea has long been associated with a reduced risk of cancer development. (-)-Epicatechin-3-gallate (ECG) or (-)-epigallocatechin- 3-gallate (EGCG) are the major antioxidative polyphenolic compounds of green tea. They have been shown to exert growth-inhibitory potential of various cancer cells in culture and antitumor activity in vivo models. ECG or EGCG could interact with various molecules like proteins, transcription factors, and enzymes, which block multiple stages of carcinogenesis via regulating intracellular signaling transduction pathways. Moreover, ECG and EGCG possess pharmacological and physiological properties including induction of phase II enzymes, mediation of anti-inflammation response, regulation of cell proliferation and apoptosis effects and prevention of tumor angiogenesis, invasion and metastasis. Numerous review articles have been focused on EGCG, however none have been focused on ECG despite many studies supporting the cancer preventive potential of ECG. To develop ECG as an anticarcinogenic agent, more clear understanding of the cell signaling pathways and the molecular targets responsible for chemopreventive and chemotherapeutic effects are needed. This review summarizes recent research on the ECG-induced cellular signal transduction events which implicate in cancer management.

原文English
頁(從 - 到)101-110
頁數10
期刊Food and Function
2
發行號2
DOIs
出版狀態Published - 2011 二月 1

指紋

chemoprevention
Chemoprevention
epicatechin
carcinogenesis
Carcinogenesis
epigallocatechin
neoplasms
Neoplasms
green tea
Tea
Anticarcinogenic Agents
Enzymes
enzymes
angiogenesis
epicatechin gallate
metastasis
signal transduction
Signal Transduction
cell proliferation
polyphenols

All Science Journal Classification (ASJC) codes

  • Food Science

引用此文

Pan, Min Hsiung ; Chiou, Yi Siou ; Wang, Ying-Jan ; Ho, Chi Tang ; Lin, Jen Kun. / Multistage carcinogenesis process as molecular targets in cancer chemoprevention by epicatechin-3-gallate. 於: Food and Function. 2011 ; 卷 2, 編號 2. 頁 101-110.
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Multistage carcinogenesis process as molecular targets in cancer chemoprevention by epicatechin-3-gallate. / Pan, Min Hsiung; Chiou, Yi Siou; Wang, Ying-Jan; Ho, Chi Tang; Lin, Jen Kun.

於: Food and Function, 卷 2, 編號 2, 01.02.2011, p. 101-110.

研究成果: Review article

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AU - Lin, Jen Kun

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