Murine typhus in Southern Taiwan during 1992-2009

Ko Chang, Yen Hsu Chen, Nan Yao Lee, Hsin Chun Lee, Chun Yu Lin, Jih Jin Tsai, Po Liang Lu, Tun Chieh Chen, Hsiao Chen Hsieh, Wei Ru Lin, Ping Chang Lai, Chia Ming Chang, Chi Jung Wu, Chung Hsu Lai, Wen Chien Ko

研究成果: Article

17 引文 斯高帕斯(Scopus)


Clinical information regarding murine typhus in Taiwan is limited. In this study, 81 cases of serologically documented murine typhus during 1992-2009 at four referral hospitals in southern Taiwan were analyzed. There was a significant correlation between average environmental temperature and case numbers of murine typhus (r = 0.747, P = 0.005). Acute hepatitis was found in 67% of cases, and hyperbilirubinemia (serum total bilirubin ≥ 23.9 μmol/L) was found in 38%. The intervals between the initiation of appropriate therapy to defervescence were longer in patients with hyperbilirubinemia than those without hyperbilirubinemia (6.1 versus 4.1 days; P = 0.015). Nine (11.1%) showed development of severe illnesses such as acute respiratory distress syndrome (2 patients), aseptic meningitis (3), and acute renal failure (4). Only one died of acute respiratory distress syndrome. Cases of murine typhus were often found during the summer and had acute febrile hepatitis. Those patients with hyperbilirubinemia tended to have a delayed recovery even with appropriate therapy.

頁(從 - 到)141-147
期刊American Journal of Tropical Medicine and Hygiene
出版狀態Published - 2012 七月 1

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Virology
  • Infectious Diseases

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    Chang, K., Chen, Y. H., Lee, N. Y., Lee, H. C., Lin, C. Y., Tsai, J. J., Lu, P. L., Chen, T. C., Hsieh, H. C., Lin, W. R., Lai, P. C., Chang, C. M., Wu, C. J., Lai, C. H., & Ko, W. C. (2012). Murine typhus in Southern Taiwan during 1992-2009. American Journal of Tropical Medicine and Hygiene, 87(1), 141-147.