Mushroom body glycolysis is required for olfactory memory in Drosophila

Chia Lin Wu, Ching Ching Chang, Jie Kai Wu, Meng Hsuan Chiang, Chu Huai Yang, Hsueh Cheng Chiang

研究成果: Article同行評審

11 引文 斯高帕斯(Scopus)


Glucose catabolism, also known as glycolysis, is important for energy generation and involves a sequence of enzymatic reactions that convert a glucose molecule into two pyruvate molecules. The glycolysis process generates adenosine triphosphate as a byproduct. In this study, we investigated whether glycolysis plays a role in maintaining neuronal functions in the Drosophila mushroom bodies (MBs), which are generally accepted to be an olfactory learning and memory center. Our data showed that individual knockdown of glycolytic enzymes in the MBs, including hexokinase (HexA), phosphofructokinase (Pfk), or pyruvate kinase (PyK), disrupts olfactory memory. Whole-mount brain immunostaining indicated that pyruvate kinase is strongly expressed in the MB αβ, α′β′, and γ neuron subsets. We conclude that HexA, Pfk, and PyK are required in each MB neuron subset for olfactory memory formation. Our data therefore indicates that glucose catabolism in the MBs is important for olfactory memory formation in Drosophila.

頁(從 - 到)13-19
期刊Neurobiology of Learning and Memory
出版狀態Published - 2018 4月

All Science Journal Classification (ASJC) codes

  • 實驗與認知心理學
  • 認知神經科學
  • 行為神經科學


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