N-nitrosamines in drinking water and beer: Detection and risk assessment

Chun Cheng Fan, Tsair Fuh Lin

研究成果: Article同行評審

59 引文 斯高帕斯(Scopus)


Occurrence and risk related to nitrosamines, a group of carcinogenic compounds found in some drinking waters and beer, are studied. An analytical method using a solid-phase micro-extraction (SPME) along with gas chromatography (GC) and mass spectrometry (MS) was developed to determine seven N-nitrosamines in drinking water and beer, including N-nitrosomethylamine (NMEA), N-nitrosodiethylamine (NDEA), N-nitrosodimethylamine (NDMA), N-nitrosodi-n-propylamine (NDPA), N-nitrosopyrrolidine (NPyr), N-nitrosopiperidine (NPip), and N-nitrosodinbutylamine (NDBA). The analysis can be completed in 70 min, and only a 4 mL sample is required, with a detection limit of 0.1–0.8 ng/L for the seven nitrosamines in water and 6–15.7 ng/L in beer. The method was applied to analyze water samples collected from 11 reservoirs and their associated drinking water treatment plants in Taiwan and 10 beer samples from 6 brands with factories located in 6 countries. In the drinking water samples, all seven N-nitrosamines were detected, with NDMA having the highest level at 10.2 ng/L. In the beer samples, NDMA was detected at much lower concentrations (0.12–0.23 μg/L) than the 5 μg/L US standard, while NPip was detected at much higher concentrations (4.1–5.3 μg/L) compared to NDMA. The risk assessment indicates that the risk associated with NDMA is the highest among the studied N-nitrosamines in Taiwan's drinking water, with an average cancer risk of 6.4 × 10−06. For other nitrosamines, the risks are all below 10−6. For the risks associated with N-nitrosamines in beer, NDMA, NDEA, NDPA, and NPip are in the range of 1.5 × 10−05 to 4.6 × 10−04, while that for other nitrosamines are much lower. As for beer, no information for NPip and no modern information for NDEA and NDPA have previously been available, more studies about nitrosamines in beer are suggested for better estimation and control of the risks associated with consumption of beer.

頁(從 - 到)48-56
出版狀態Published - 2018 6月

All Science Journal Classification (ASJC) codes

  • 環境工程
  • 環境化學
  • 一般化學
  • 污染
  • 健康、毒理學和誘變


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