Naloxone prolongs cutaneous nociceptive block by lidocaine in rats

Yu Wen Chen, Ja Ping Shieh, Kuo Sheng Liu, Jhi Joung Wang, Ching Hsia Hung

研究成果: Article

4 引文 (Scopus)

摘要

We aimed to investigate the local anesthetic properties of naloxone alone or as an adjunct for the local anesthetic lidocaine. After the block of the cutaneous trunci muscle reflex (CTMR) with drugs delivery by subcutaneous infiltration, cutaneous nociceptive block was tested on the ratsꞌ backs. We demonstrated that naloxone, as well as lidocaine, elicited cutaneous analgesia dose-dependently. The relative potency in inducing cutaneous analgesia was lidocaine [22.6 (20.1 – 25.4) μmol/kg] > naloxone [43.2 (40.3 – 46.4) μmol/kg] (P < 0.05). On an equianesthetic basis [50% effective dose (ED50), ED25, and ED75], naloxone displayed a greater duration of cutaneous analgesic action than lidocaine (P < 0.01). Coadministration of lidocaine (ED95 or ED50) and ineffective-dose naloxone (13.3 μmol/kg) intensifies sensory block (P < 0.01) with prolonged duration of action (P < 0.001) compared with lidocaine (ED95 or ED50) alone or naloxone (13.3 μmol/kg) alone on infiltrative cutaneous analgesia. The preclinical data showed that naloxone is less potent than lidocaine as an infiltrative anesthetic, but its analgesic duration was longer than that of lidocaine. Furthermore, naloxone prolongs lidocaine analgesia, acting synergistically for nociceptive block.

原文English
頁(從 - 到)636-642
頁數7
期刊Fundamental and Clinical Pharmacology
31
發行號6
DOIs
出版狀態Published - 2017 十二月

指紋

Naloxone
Lidocaine
Skin
Analgesia
Local Anesthetics
Analgesics
Reflex
Anesthetics
Muscles

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

引用此文

Chen, Yu Wen ; Shieh, Ja Ping ; Liu, Kuo Sheng ; Wang, Jhi Joung ; Hung, Ching Hsia. / Naloxone prolongs cutaneous nociceptive block by lidocaine in rats. 於: Fundamental and Clinical Pharmacology. 2017 ; 卷 31, 編號 6. 頁 636-642.
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Naloxone prolongs cutaneous nociceptive block by lidocaine in rats. / Chen, Yu Wen; Shieh, Ja Ping; Liu, Kuo Sheng; Wang, Jhi Joung; Hung, Ching Hsia.

於: Fundamental and Clinical Pharmacology, 卷 31, 編號 6, 12.2017, p. 636-642.

研究成果: Article

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AB - We aimed to investigate the local anesthetic properties of naloxone alone or as an adjunct for the local anesthetic lidocaine. After the block of the cutaneous trunci muscle reflex (CTMR) with drugs delivery by subcutaneous infiltration, cutaneous nociceptive block was tested on the ratsꞌ backs. We demonstrated that naloxone, as well as lidocaine, elicited cutaneous analgesia dose-dependently. The relative potency in inducing cutaneous analgesia was lidocaine [22.6 (20.1 – 25.4) μmol/kg] > naloxone [43.2 (40.3 – 46.4) μmol/kg] (P < 0.05). On an equianesthetic basis [50% effective dose (ED50), ED25, and ED75], naloxone displayed a greater duration of cutaneous analgesic action than lidocaine (P < 0.01). Coadministration of lidocaine (ED95 or ED50) and ineffective-dose naloxone (13.3 μmol/kg) intensifies sensory block (P < 0.01) with prolonged duration of action (P < 0.001) compared with lidocaine (ED95 or ED50) alone or naloxone (13.3 μmol/kg) alone on infiltrative cutaneous analgesia. The preclinical data showed that naloxone is less potent than lidocaine as an infiltrative anesthetic, but its analgesic duration was longer than that of lidocaine. Furthermore, naloxone prolongs lidocaine analgesia, acting synergistically for nociceptive block.

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