@inproceedings{c6374b0d771943b0a91683419c4ca137,
title = "Nanoparticle-mediated in-vitro gene transfection on the micro electroporation chip",
abstract = "Gold nanoparticles modified with 21-based thiolated-oligonucleotides have been utilized as novel gene delivery vehicles for electroporation on microchips in the present study. The electroporation chip, consisting of a defined cell culture cavity region with thin film electrodes made of titanium and gold, was fabricated on a glass slide using microfabrication technologies. The electric field for the Au-DNA conjugates attracting was generated to induce the electrophoresis of Au-DNA conjugates and enhance the transfection efficient on the electroporation microchip. Both the UV-vis spectra of the surface plasmon resonance and TEM micrographs indicated that the nanoparticles associated with DNA could be delivered into cells utilizing electroporation. This investigation had demonstrated the nanoparticle-based gene delivery system.",
author = "Jen, {Chun Ping} and Fan, {Chun Sheng} and Yu-Cheng Lin and Yu-Hung Chen and Lee, {Chia Wei} and Chen-Sheng Yeh",
year = "2003",
month = jan,
day = "1",
doi = "10.1109/SENSOR.2003.1216948",
language = "English",
series = "TRANSDUCERS 2003 - 12th International Conference on Solid-State Sensors, Actuators and Microsystems, Digest of Technical Papers",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "1047--1050",
booktitle = "TRANSDUCERS 2003 - 12th International Conference on Solid-State Sensors, Actuators and Microsystems, Digest of Technical Papers",
address = "United States",
note = "12th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2003 - Digest of Technical Papers ; Conference date: 08-06-2003 Through 12-06-2003",
}