TY - GEN
T1 - Nanoshell magnetic resonance imaging contrast agents
AU - Su, Chia Hao
AU - Sheu, Hwo Shuenn
AU - Lin, Chia Yun
AU - Huang, Chih Chia
AU - Lo, Yi Wei
AU - Pu, Ying Chih
AU - Weng, Jun Cheng
AU - Shieh, Dar Bin
AU - Chen, Jyh Horng
AU - Yeh, Chen Sheng
PY - 2007
Y1 - 2007
N2 - In our studies, Au3Cu1 hollow nanostructures are believed to be the first bimetallic MR contrast agents. AU3CU 1 nanocapsules enhanced signal contrast not only in Ti-weighted imaging, but also in T2-weighted imaging at lower doses. Herein, we believe that the cooperativity originating from the form of the nanoparticles and the large surface area of the water, because of porous hollow morphology of the nanoparticle, are primarily involved. Furthermore, the amine groups on the outermost PEI polymer shell of the nanocapsules, which further provide surface modification for the attachment of biological signals, suggest great potential for use in multifunctional composite capsules as functional carriers and imaging agents. Overall, these results might lead to the creation of other non-Gd- and non-iron oxide-based bimetallic contrast agents.
AB - In our studies, Au3Cu1 hollow nanostructures are believed to be the first bimetallic MR contrast agents. AU3CU 1 nanocapsules enhanced signal contrast not only in Ti-weighted imaging, but also in T2-weighted imaging at lower doses. Herein, we believe that the cooperativity originating from the form of the nanoparticles and the large surface area of the water, because of porous hollow morphology of the nanoparticle, are primarily involved. Furthermore, the amine groups on the outermost PEI polymer shell of the nanocapsules, which further provide surface modification for the attachment of biological signals, suggest great potential for use in multifunctional composite capsules as functional carriers and imaging agents. Overall, these results might lead to the creation of other non-Gd- and non-iron oxide-based bimetallic contrast agents.
UR - http://www.scopus.com/inward/record.url?scp=47349095397&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=47349095397&partnerID=8YFLogxK
U2 - 10.1109/IMNC.2007.4456209
DO - 10.1109/IMNC.2007.4456209
M3 - Conference contribution
AN - SCOPUS:47349095397
SN - 4990247248
SN - 9784990247249
T3 - Digest of Papers - Microprocesses and Nanotechnology 2007; 20th International Microprocesses and Nanotechnology Conference, MNC
SP - 272
EP - 273
BT - Digest of Papers - Microprocesses and Nanotechnology 2007; 20th International Microprocesses and Nanotechnology Conference, MNC
T2 - s20th International Microprocesses and Nanotechnology Conference, MNC 2007
Y2 - 5 November 2007 through 8 November 2007
ER -