NAT2 slow acetylation haplotypes are associated with the increased risk of betel quidrelated oral and pharyngeal squamous cell carcinoma

Yu Yi Hou, Hui Ling Ou, Sau Tung Chu, Pi Chuang Wu, Pei Jung Lu, Chao Chuan Chi, Kam Wing Leung, Chien Yiing Lee, Pi Hsiung Wu, Michael Hsiao, Luo Ping Ger

研究成果: Article同行評審

12 引文 斯高帕斯(Scopus)

摘要

Background: NAT2, the most important phase II metabolic enzyme for betel quid (BQ), might modify the risk of BQ-related oral and pharyngeal squamous cell carcinoma (OPSCC) in Taiwan. Study design: PCR-RFLP and TaqMan assay were conducted for genotyping of NAT2 in 172 OPSCC cases and 170 healthy controls who habitually chewed BQ. Results: The genotypic and allelic type of T341C and C481T in NAT2 are associated with the risk of OPSCC. There were linear trends between increased risk of OPSCC and slowness of NAT2 acetylation haplotypes (P =.017), especially for young subjects (P <.001), light BQ chewers (P =.005), light smokers (P =.023), and alcohol drinkers (P =.001). The interactions on risk of OPSCC were found for NAT2 acetylation haplotypes with status of age, BQ chewing, and alcohol drinking. Conclusions: The NAT2 acetylation haplotypes might be genetic markers for risk of BQ-related OPSCC.

原文English
頁(從 - 到)484-492
頁數9
期刊Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
112
發行號4
DOIs
出版狀態Published - 2011 十月

All Science Journal Classification (ASJC) codes

  • 手術
  • 口腔外科
  • 耳鼻咽喉科
  • 牙科 (全部)

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