Near-diploid transitional cell carcinoma: A preliminary report

N. H. Chow, T. S. Tzai, S. N. Lin, W. C. Su, H. L. Cheng

研究成果: Article

摘要

DNA ploidy analysis has been accepted as an important prognostic factor for patients with transitional cell carcinoma (TCC). However, there was few information dealing with the clinical relevance of slightly aberrant DNA content by flow cytometry (FCM). Here we present five cases of near-diploid (ND) tumours, with DNA index (DI) varying from 0.92 to 1.14, obtained from a prospective study of fifty-one cases (9.8%). The frequency of ND tumours showed a tendency to decrease with increasing tumour stage. Higher fraction of tumour proliferation, defined by Ki-67 index, showed a steady increment from 3.4 to 23.5% with occurrence of gross chromosomal changes. In contrast, the expression of epidermal growth factor receptor (EGFR) decreased from 48.3 to 35.3% for diploid (n=29) through aneuploid (n=17) tumours. All three ND bladder cancers had recurrence of one to three times with median follow-up of 36 months. The incidences of tumour recurrence (60%) and cancer death (20%) in ND tumours were intermediate between the aneuploid and diploid TCCs. But, flow DNA analysis of paraffin-embedded ND tumours revealed wide and symmetrical G0/G1 peak with DI varying from 5.6 to 13.0. Our limited experience suggests the necessity of special treatment for G0/G1 peaks having CV values greater than 5.5% from paraffin-embedded urothelial carcinomas.

原文English
頁(從 - 到)423-430
頁數8
期刊International Urology and Nephrology
26
發行號4
DOIs
出版狀態Published - 1994 十二月 1

指紋

Transitional Cell Carcinoma
Diploidy
Neoplasms
DNA
Aneuploidy
Paraffin
Recurrence
Ploidies
Epidermal Growth Factor Receptor
Urinary Bladder Neoplasms
Flow Cytometry
Prospective Studies
Carcinoma
Incidence

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Urology

引用此文

@article{2940e82cefd14777954c6fc345933a64,
title = "Near-diploid transitional cell carcinoma: A preliminary report",
abstract = "DNA ploidy analysis has been accepted as an important prognostic factor for patients with transitional cell carcinoma (TCC). However, there was few information dealing with the clinical relevance of slightly aberrant DNA content by flow cytometry (FCM). Here we present five cases of near-diploid (ND) tumours, with DNA index (DI) varying from 0.92 to 1.14, obtained from a prospective study of fifty-one cases (9.8{\%}). The frequency of ND tumours showed a tendency to decrease with increasing tumour stage. Higher fraction of tumour proliferation, defined by Ki-67 index, showed a steady increment from 3.4 to 23.5{\%} with occurrence of gross chromosomal changes. In contrast, the expression of epidermal growth factor receptor (EGFR) decreased from 48.3 to 35.3{\%} for diploid (n=29) through aneuploid (n=17) tumours. All three ND bladder cancers had recurrence of one to three times with median follow-up of 36 months. The incidences of tumour recurrence (60{\%}) and cancer death (20{\%}) in ND tumours were intermediate between the aneuploid and diploid TCCs. But, flow DNA analysis of paraffin-embedded ND tumours revealed wide and symmetrical G0/G1 peak with DI varying from 5.6 to 13.0. Our limited experience suggests the necessity of special treatment for G0/G1 peaks having CV values greater than 5.5{\%} from paraffin-embedded urothelial carcinomas.",
author = "Chow, {N. H.} and Tzai, {T. S.} and Lin, {S. N.} and Su, {W. C.} and Cheng, {H. L.}",
year = "1994",
month = "12",
day = "1",
doi = "10.1007/BF02768013",
language = "English",
volume = "26",
pages = "423--430",
journal = "International Urology and Nephrology",
issn = "0301-1623",
publisher = "Springer Netherlands",
number = "4",

}

Near-diploid transitional cell carcinoma : A preliminary report. / Chow, N. H.; Tzai, T. S.; Lin, S. N.; Su, W. C.; Cheng, H. L.

於: International Urology and Nephrology, 卷 26, 編號 4, 01.12.1994, p. 423-430.

研究成果: Article

TY - JOUR

T1 - Near-diploid transitional cell carcinoma

T2 - A preliminary report

AU - Chow, N. H.

AU - Tzai, T. S.

AU - Lin, S. N.

AU - Su, W. C.

AU - Cheng, H. L.

PY - 1994/12/1

Y1 - 1994/12/1

N2 - DNA ploidy analysis has been accepted as an important prognostic factor for patients with transitional cell carcinoma (TCC). However, there was few information dealing with the clinical relevance of slightly aberrant DNA content by flow cytometry (FCM). Here we present five cases of near-diploid (ND) tumours, with DNA index (DI) varying from 0.92 to 1.14, obtained from a prospective study of fifty-one cases (9.8%). The frequency of ND tumours showed a tendency to decrease with increasing tumour stage. Higher fraction of tumour proliferation, defined by Ki-67 index, showed a steady increment from 3.4 to 23.5% with occurrence of gross chromosomal changes. In contrast, the expression of epidermal growth factor receptor (EGFR) decreased from 48.3 to 35.3% for diploid (n=29) through aneuploid (n=17) tumours. All three ND bladder cancers had recurrence of one to three times with median follow-up of 36 months. The incidences of tumour recurrence (60%) and cancer death (20%) in ND tumours were intermediate between the aneuploid and diploid TCCs. But, flow DNA analysis of paraffin-embedded ND tumours revealed wide and symmetrical G0/G1 peak with DI varying from 5.6 to 13.0. Our limited experience suggests the necessity of special treatment for G0/G1 peaks having CV values greater than 5.5% from paraffin-embedded urothelial carcinomas.

AB - DNA ploidy analysis has been accepted as an important prognostic factor for patients with transitional cell carcinoma (TCC). However, there was few information dealing with the clinical relevance of slightly aberrant DNA content by flow cytometry (FCM). Here we present five cases of near-diploid (ND) tumours, with DNA index (DI) varying from 0.92 to 1.14, obtained from a prospective study of fifty-one cases (9.8%). The frequency of ND tumours showed a tendency to decrease with increasing tumour stage. Higher fraction of tumour proliferation, defined by Ki-67 index, showed a steady increment from 3.4 to 23.5% with occurrence of gross chromosomal changes. In contrast, the expression of epidermal growth factor receptor (EGFR) decreased from 48.3 to 35.3% for diploid (n=29) through aneuploid (n=17) tumours. All three ND bladder cancers had recurrence of one to three times with median follow-up of 36 months. The incidences of tumour recurrence (60%) and cancer death (20%) in ND tumours were intermediate between the aneuploid and diploid TCCs. But, flow DNA analysis of paraffin-embedded ND tumours revealed wide and symmetrical G0/G1 peak with DI varying from 5.6 to 13.0. Our limited experience suggests the necessity of special treatment for G0/G1 peaks having CV values greater than 5.5% from paraffin-embedded urothelial carcinomas.

UR - http://www.scopus.com/inward/record.url?scp=0027936163&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027936163&partnerID=8YFLogxK

U2 - 10.1007/BF02768013

DO - 10.1007/BF02768013

M3 - Article

C2 - 8002215

AN - SCOPUS:0027936163

VL - 26

SP - 423

EP - 430

JO - International Urology and Nephrology

JF - International Urology and Nephrology

SN - 0301-1623

IS - 4

ER -